Mangiarua - Tubular ecretion Flashcards
Clearance of PAH _______ true renal plasma flow by 10%
Underestimates
The fraction of a substance which is removed by the kidneys
Extraction ratio
Net urate flux is predominantly _____
Reabsorption
Uric acid represents ____ % of total urinary nitrogen
5%
Is urate freely filterable?
Yes
The secretory process of net urate flux is -______ regulated
Homeostatically
Four factors which may play a role in the production of hyperuricemia
Decreased filtration rate w/ maintained tubular reabsoprtion
Increased reabsorption of urate
Decreased secretion of urate
Increased production of urate
__ % of filtered load of K reabsorbed in proximal tubule
67
___% of filtered load of K reabsorbed in the thick ascending limb of loop of henle
20%
The principal cell, in the connecting tubule and cortical collecting duct, when stimulated by aldosterone, will secrete ____
K+
Determinants of K Secretion
[K] gradient between principal cell and tubular fluid
Flow rate of tubular fluid
Electrical gradient across luminal membrane of K secreting cells
Poorly reabsorbed anions in the tubular fluid
Aldosterone
Systemic acid-base status
What does increased tubular fluid flow do to the potassium secretion?
Increases potassium secretion because the tubular fluid [K] is kept low, maintaining a high [K] gradient
What causes increased K+ secretion from diuretics?
Na reabsorption in the ascending thick loop of henle is decreased, decreased water retention, this increases flow in the tubule and increases [K+] gradient.
Aldosterone stimulates the secretion of ?
K and H
Reabsorption of Na
Primary hypermineralocorticoidism causes ?
Hypertension (increased Na reabsorption)
Hypokalemia (increased K secretion)
Metabolic Alkalosis (increased H+ secretion)
