Management of Type 2 Diabetes Mellitus Part 2 Flashcards
What are incretins?
Group of metabolic hormones that stimulate a decrease in blood glucose levels, they are released after eating from pancreatic beta cells
How is the incretin effect altered in T2 diabetes?
It is diminished
What are the 2 types of incretins?
…gliptins
…tides
What are the …gliptins?
DPPIV-inhibitors
What are examples of …gliptins?
Saxagliptin
Sitagliptin
Vildagliptin
What effect do …gliptins have?
Increase insulin release
What is the mode of action of gliptins?
Delay breakdonw of incretins and thereby increase active incretin levels, causing
What are advantages of gliptins?
What are disadvantages of gliptins?
What are examples of …tides?
Exenatide
Liraglutide
Lixsenatide
What are …tides?
GLP-1 analogues
What effect do GLP-1 analogues (…tides) have?
Increase insulin release
What is the mode of action of GLP1?
What is a common side effect of incretin-mimetics?
Nausea
What GLP1 analogue can be given in a pen device?
Exenatide