Malignant Haematology

Question 1

Common reactive causes for high/low counts

Answer 1

Chronic hypoxia, diuretc use etc. and high Hb,
Infection, steroids and neutrophilia,
Blood loss and thrombocytosis,
Non-neoplastic causes of anaemia,
Non-neoplastic causes of thrombocytopaenia
Hypersplenism & pancytopenia normal causes

Question 2

Blasts appearance on blood film

Answer 2

High N:C ratio,
Prominent nucleoli,
Smooth chromatin,
V large

Question 3

Stepwise order of events of investigations

Answer 3

Morpholy,
Immunophenotyping,
Cytogenetics,
Molecular genetics

Question 4

Acute leukaemia affects which compartments

Answer 4

More primitvie

Question 5

In neutropenic patient which type of organism is most likely to be fatal within hours if untreated

Answer 5

Gram negative bacillus

Question 6

For solid organ tumour e.g. lymphoma if you want to identify what test should you do to confirm diagnosis?

Answer 6

Immunohistochemistry