Blood Groups & Donation

Question 1

Minimum Hb criteria for men to donate blood?

Answer 1

135g/L

Question 2

Minimum Hb criteria for women to donate blood?

Answer 2

125g/L

Question 3

Minimum weight for blood donors?

Answer 3

50kg

Question 4

Blood donation samples undergo microbiological testing for what 6 diseases?

Answer 4

HIV, 
Hep B, 
Hep C, 
Hep E, 
HTLF, 
Syphilis

Question 5

At what temp and for how long is FFP stored for?

Answer 5

stored at 4 degrees for 35 days

Question 6

At what temp and for how long is FFP stored for?

Answer 6

stored at -30 degrees for 3 years

Question 7

At what temp and for how long is FFP stored for?

Answer 7

stored at 22 degrees for 7 days with agitation (shaking)

Question 8

What blood components are available for transfusion from lab? (4)

Answer 8

red cells,
FFP,
platelets,
cryoprecipitate (source of fibrinogen)

Question 9

Give 2 examples of blood products available for transfusion from lab

Answer 9

Anti-D immunoglobulin,

prothrombin complex concentrate (reverse warfarin)

Question 10

Give 3 examples of blood products available from pharmacy?

Answer 10

IV immunoglobulin,
human albumin,
specific Ig e.g. zoster Ig

Question 11

ABO system coded for chromosome on what chromosome?

Answer 11

Chromosome

Question 12

A and B genes code for what?

Answer 12

for transferases which modify precursor called H substance on red cell membrane

Question 13

What does it mean that O is silent in ABO?

Answer 13

O means you lack A or B so both A and B groups so you don’t express A or B antigens on your RBCs

Question 14

A and B are dominant over O and A is dominant over B. T/F?

Answer 14

FAlse!! A and B are dominant over O and A and B are co-dominant

Question 15

What is most common ABO group from most to least and their population frequency percentage?

Answer 15

O - 47%,
A - 42%,
B - 8%,
AB - 3%

Question 16

What is difference between phenotype and genotype with blood groups?

Answer 16

Phenotype is which antigens are detected whereas genotype which genes are present

Question 17

Genotype of phenotype Group O?

Answer 17

OO

Question 18

Genotypes of phenotype Group A?

Answer 18

AA or AO

Question 19

Genotypes of phenotype Group B?

Answer 19

BB or BO

Question 20

Genotype of phenotype Group AB?

Answer 20

AB

Question 21

What does Landsteiner’s Law state?

Answer 21

When an individual lacks the A or B antigen, the corresponding antibody is produced in their plasma

Question 22

Blood group A express what antibodies in their plasma?

Answer 22

anti-B

Question 23

Blood group B express what antibodies in their plasma?

Answer 23

anti-A

Question 24

Blood group O express what antibodies in their plasma?

Answer 24

anti-A and anti-B

Question 25

Blood group AB express what antibodies in their plasma?

Answer 25

neither

Question 26

Blood group O can receive what blood?

Answer 26

only other O

Question 27

Blood group A can receive what blood?

Answer 27

only A and O

Question 28

Blood group B can receive what blood?

Answer 28

only B and O

Question 29

Blood group AB can receive what blood?

Answer 29

all types

Question 30

85% of population are RhD positive/negative?

Answer 30

positive

Question 31

RhD + genotype?

Answer 31

DD or Dd

Question 32

RhD - genotype?

Answer 32

dd

Question 33

Anti-D antibody can cause what 2 types of reactions?

Answer 33

transfusion reactions,

haemolytic disease of the foetus/newborn

Question 34

RhD positive blood should NEVER be given to RhD negative patients. T/F?

Answer 34

True

Question 35

Although less immunogenic than ABO and Rh systems, when might other blood group systems lead to transfusion reaction?

Answer 35

if sensitised to exposure to foreign antigens by pregnancy/transfusion, repeat exposure can cause transfusion reaction

Question 36

What is antisera and what is regent red cells? How do they interact?

Answer 36

antisera: reagant with known antibody specificity used to identify antigens present on red cells,
reagant red cells: red cells with known antigen specificity to identify antibodies in plasma
together there is agglutination of red cells

Question 37

How is blood ABO/D grouping tested?

Answer 37

test patient’s red cells with anti-A, anti-B and anti-D antisera