Male Sex Hormones

Question 1

What does the Y chromosome give info for?

Answer 1

Testosterone and MIS

Question 2

What happens when MIS is present?

Answer 2

Mullierian duct disintegrates and the wolffian duct proliferates to develop male internal genitalia

Question 3

What does the placenta produce which later produces testosterone

Answer 3

HcG -> human chorionic gonadotropin

Question 4

What hormone is needed for the differentiation from female external genitalia to male external genitalia

Answer 4

Dehydrotestosterone

Question 5

How long does it take for the develop,met of male external genitalia??

Answer 5

9-12 weeks gestation

Question 6

What enzyme do Sertoli cells have

Answer 6

Aromatase

Question 7

What does aromatase do?

Answer 7

Converts testosterone to estrogen

Question 8

What kind of receptors do Sertoli cells have and lack

Answer 8

Have: FSH receptors
Lack: LH receptors

Question 9

What receptors do leydig cells have and don’t have?

Answer 9

Have: LH
Lack: FSH

Question 10

What does LH do in leydig cells

Answer 10

Increase cAMP levels which increases steroidogenesis

Question 11

What does testosterone produce

Answer 11

Internal organs

Question 12

What does dehydrotestosterone produce

Answer 12

External organs

Question 13

How are androgens transported?

Answer 13

Bound to proteins (either SHBG or albumin)

Question 14

What do Sertoli cells produce that targets AP to stop producing FH

Answer 14

Inhibin

Question 15

What does testosterone do during puberty

Answer 15

Bone growth, and epiphyseal closure then there’s a decrease in bone growth. There’s also the maturation of internal and external genitalia

Question 16

What’s the concentration difference between androgens inside the cell and in the blood?

Answer 16

In the cell, androgen levels are 200 times higher. This is important for spermatogenesis

Question 17

What can be the result of high levels of exogenous androgens?

Answer 17

Infertility

Question 18

As men age what happens?

Answer 18

Decrease in gonadal sensitivity to LH, decreased androgen production and increase in LH & FSH

Question 19

What happens when men are hyperprolactin?

Answer 19

It inhibits male reproductive function and leads to infertility

Question 20

What’s klinefleters syndrome

Answer 20

XXY

Question 21

What Happens when there’s 5-alpha Reductsse deficiency?

Answer 21

Decreased dihydrotestosterone so there’s normal male internal genitalia but incomplete masculine external genitalia

Question 22

What happens when there’s androgen insensitivity syndrome?

Answer 22

They lack internal genitalia, have female external genitalia, lack menstruation etc

Question 23

What’s another name for androgen insensitivity syndrome

Answer 23

Testicular feminization

Question 24

What happens with congenital adrenal hyperplasia?

Answer 24

It happens when an enzyme activity is reduced causing lower cortisol synthesis but increased androgen synthesis. The androgens virilize external genitalia. It’s when excess cholesterol is converted to androgens

Question 25

What’s the aromatization hypothesis

Answer 25

It explains how brain masculinization is caused by high levels of estrogen. It’s when brain masculinization occurs when testosterone is converted to estrogen

Question 26

What’s turners syndrome

Answer 26

It’s when they have XO chromosomes. They’re sexed as girls but lack a second X chromosome.