Male Repro Physiology Flashcards
1
Q
Sertoli Cell Functions
A
- Regulate Spermatogenesis
- Form Blood-testes barrier
- Protect f/ autoimmune attack
- Secrete inhibin B
- Secrete ABP
- Produce Anti-mullerian hormone
2
Q
Function of Cells of Leydig
A
- Secrete testosterone in response to LH
3
Q
Negative feedback Male Repro
A
- Inhibin + Testosterone inhibits Anterior Pituitary
- Estradiol Inhibits Hypothalamus
4
Q
Cause of Puberty acne
A
Androgen receptors on sebaceous glands increase sebum production
5
Q
Androgen mediator in androgenic alopecia
A
DHT
6
Q
Affect of exogenous testosterone on tEstes
A
Supresses LH -> DEC endogenous Testosterone -> DEC Spermatogenesis
7
Q
How does high temperatures affect the testes
A
- DEC Spermatogenesis
- DEC inhibin -> INC FSH
8
Q
DHT Uses
A
BPH + Alopecia
9
Q
5 a-reductase deficiency
- Genetics
- Path
- S/S
A
- Autosomal Recessive
- PAth: Able to path testosterone, but not DHT
- S/S: Normal internal genitalia; abnormal external; blind-ending vagina
10
Q
Treatment for Male Hypogonadism
A
Testosterone
11
Q
What is a major side effect of Spironoloactine? What is a good substitute?
A
- Gynecomastia, hisrutism, Alopecia in women
- Use eplerenone as alternate
12
Q
Complete Androgen Insensitivity Syndrome (CAIS)
- Genetics
- Path
- S/S
A
- Androgen receptor mutation in makes
- Path: No cellular response to androgens
- S/S: Absent Fallopian tubes/uterus; No internal or external make genital development; Amenorrhea, Abdominal testes;
13
Q
Cryptorchidism
A
- Hidden/undescended Testes
- Abdominal or Inguinal; Unilateral or bilateral
- INC Risk tumor
14
Q
Varicocele
- Cause
- S/S
- Tx
A
- Dilation of Pampoiniform plexus of spermatic vein due toi obstruction, comporession, etc
- S/S: Scrotal swelling + pain; Infertility
- Tx: Varicocelectomy; embolization
