Pharm Gluco/Mineralocorticoids Flashcards
1
Q
Metabolic affects Glucocorticoids
A
- Stimulate GNG
- Inhibit glucose uptake by adipose/muscle
- Glycogen deposition in Liver
- INC Insulin Secreiton
- Catabolic effects on Bone + CT (Osteoporosis)
2
Q
Anti-inflammatory mech glucocorticoids
A
- Inhibit PLA-1
- Reduce COX-2 expression
- Both reduce PGEs
- DEC Cell-mediated immunity
3
Q
GCC PK
A
- Good Oral bioavailability + Skin absorption
- Metabolized by liver/kidney
- T1/2 60-90 min
- some mineralocorticoid activity
4
Q
Classes of GCCs
A
Short-medium: Cortisone, Prednisone, prednisolone, Methylprednisolone
Intermediate: Triamcinolone
Long-lasting: Dexamethasone; Betamethasone
5
Q
Synthetic GCC indications
A
- asthma
- allergic rhinitis
6
Q
Tx of CAH
A
- Treat GC/MC replacement following Adrenalectomy
7
Q
Dexamethasone Suppression test
ACTH Values?
A
- Diagnose Cushing syndrome
- Reduces hormone levels 50%; No affect in presence of adrenal tumor or ectopic aCTH
*Reduced ACTH -> Adrenal tumor
INC ACTH -> Ectopic ACTH tumor
8
Q
Cortisol in fetus
A
Stimulate fetal lung development
9
Q
Indication of GCs
- Pulm
- Derm
- Eye
- GI
- MSK
- Other
A
- Pulmonary: Asthma, sarcoidosis
- Allergic Reactions
- Derm: AD, Psor, Xerosis, Dermatomyositis
- Eye: Acute UV, Optic neuritis, Allergic conj, Choroiditis
- GI: IBS, Crohns, UC
- MSK: Arthritis, Bursitis, Osteoarthritis
- Other; Transplantn, Infx, Col-vas Dx, Cancer. MS,mountain sickness, Hypercalcemia
10
Q
Synthetic Adrenocorticosteroid Contra
A
- Diabetes
- Peptic Ulcer
- Osteoporosis
- Glaucoma
- Infx
- Psych
- Heart Dx/CHF/HTN
11
Q
Synthetic corticosteroid employed for salt-retaining
A
Fludrocortisone acetate
12
Q
Aldosterone antagonists
- Indications
A
- Spironolactone, Eplerenone, Mifepristone
- Ind: HTN, HF, Edema, Ascites, Primary aldosteronisms, diuetic-induced hypokalemia
