MALARIA

Question 1

Plasmodium vivax

location
what it infects
how to recognize

Answer 1

8.5 million cases and found mainly in south america

infects reticulocytes via Duffy antigen

• many africans are duffy antigen negative
• has dots but are not oval shaped, have gametophytes within RBC

Question 2

Plasmodium falciparum

location
length of cycle
what it infects

Answer 2

most common and found in Africa
- 48 hour cycles

• infects any type of RBC and related with decreased risk if sickle cell trait (AS) or AC

Question 3

Plasmodium malariae

what it infects
how long is the cycle
identification

Answer 3

infect senescent RBC

• 72 hour cycles
• identified via slash RBC or rosettes in schizont

Question 4

Sexual phase of malaria

Answer 4

within the GI of the mosquito (oocytes)

Question 5

Plasmodium ovale

identification
location found

Answer 5

diagnosed with oval RBC, ring trophozoite, and granules in the cytoplasm
- mainly south america

Question 6

Treatment MOA and drugs

Answer 6

choloquine, mefloquine, quinine, quinidine

increases toxic substances to Malaria

Question 7

Atovaquone

Answer 7

structural analogue of CoQ

- disrupt membrane of malaria mito