Major functions of B cells

Question 1

Which Ab opsonizes bacteria and neutralizes viruses?

Answer 1

IgG

Question 2

Which Abs activate complement?

Answer 2

IgG, IgM

Question 3

Which Ab is involved in Type I H.S./allergy?

Answer 3

IgE

Question 4

Which Ab is involved in Cytotoxic (Type II) H.S.?

Answer 4

IgG

Question 5

Which Ab is involved in Immune complex (Type III) H.S.?

Answer 5

IgG

Question 6

What else are B cells involved in?

Answer 6

Hyperacute and humorally mediated acute and chronic organ rejection

Question 7

Steps of B-cell activation and class switching?

Answer 7

1. Helper T cell is activated.
2. B cell receptor-mediated endocytosis; Foreign body is recognized by T Helper
3. CD40 on B cell CD40L (ligand) on T Helper
4. T Helper secretes cytokines that determine B cell class switching

Question 8

if you have no B cells, which vaccine should you not be given?

Answer 8

Live Polio vaccine (Sabin)

Question 9

If you have no B cells, which fungi/parasites are you most susceptible to?

Answer 9

Giardiasis (d/t no IgA)