Madi Flashcards
Polycystic Ovary Syndrome
• Oestrogen– can be high or normal
• Total testosterone – can be high or normal
– If >5nmol/L exclude androgen secreting
tumours and CAH
• LH – may be elevated, 3:1 FSH
• FSH – mostly normal
– If LH and FSH both raised consider premature
ovarian insufficiency
– If LH and FSH both reduced consider
hypogonadotropic hypogonadism
Urine Output
• Normal urine output:
– Adult: >0.5 ml/kg/h
– Child: >1 ml/kg/h
– Infant: >2 ml/kg/h
• Measured over 6+ hrs e.g. where catheter in situ
• Other diagnostic criteria for AKI
– ↑ in serum creatinine of 26mmol/L in 48 hrs
– 50% ↑ in serum creatinine in 7 days
• Suspend nephrotoxic medication
• Ensure adequate fluid balance
• Monitor renal function + urine output
DVT Management
• If Well’s score 2+, refer for proximal leg
vein ultrasound to be done within 4 hours
• If not possible – D-dimer test if +ve:
• Give an interim anticoagulant and arrange
USS doppler within 24 hours
• Apixaban or rivaroxaban 1st line
• If DOAC not suitable
• LMWH for at least 5 days, followed by
dabigatran or edoxaban OR
• LMWH + vitamin K antagonist for 5+ days
Chronic Myeloid Leukaemia
• Rare in children
• Accounts for 15% of leukaemia
• Typically chronic insidious onset
• ~30% diagnosed incidentally
• Mean survival 5 – 6 years
• Philadelphia chromosome present in 80%
– Translocation of long arm of chromosome 9
onto long arm of chromosome 22
– Absence of Philadelphia chromosome
indicates worse prognosis
eGFR calculation
• eGFR creatinine – normal: 100ml/min/1.73m2
• Derived using CKD-EPI or MDRD equation
• Less accurate where:
• Muscle mass v. abnormal
• Age <18 or >75
• Pregnancy
• Severe malnutrition or obesity
• Rapidly changing kidney function e.g. AKI
• Vegetarian diet
• More accurate test in these groups: Cystatin C
based eGFR
Nutrition
• Consider enteral tube feeding if
– Malnourished / at risk of malnutrition +
– Inadequate / unsafe oral intake +
– Functional + accessible GI tract
• (PEG) tube –long term use (4+ weeks)
• Duodenal / jejunal tube – upper GI dysfunction /
inaccessible upper GI tract
• NG tube – acute setting, shorter term. E.g. post
stroke – 2-4 week trial
• TPN – non-functional / inaccessible / perforated
GI tract
Assessing consciousness: GCS
• Assess 3 domains: motor, verbal, eye
opening (MoVE)
• Motor = 1-6
• Verbal = 1-5
• Eye opening =1-4
• Max score = 15 (normal), Min = 3 (dead)
• 13-14 = mild head injury / loss of conc.
• 12 or less should always be scanned
Best motor response (M) - There are 6 grades starting with the most severe:
1. No motor response
2. Extension to pain
3. Abnormal flexion to pain
4. Flexion/Withdrawal to pain
5. Localises to pain
6. Obeys commands
Best verbal response (V) - There are 5 grades starting with the most severe:
1. No verbal response
2. Incomprehensible sounds (Moaning but no words.)
3. Inappropriate words
4. Confused
5. Oriented
Best eye response (E) - There are 4 grades starting with the most severe:
1. No eye opening
2. Eye opening in response to pain
3. Eye opening to speech
4. Eyes opening spontaneously
Bell’s Palsy
• Acute, unilateral, idiopathic, facial nerve paralysis
• Most make a full recovery within 9 months
• If present within 72 hours, prednisolone can improve
recovery
• Refer to ENT if
• Bilateral Bell’s palsy
• Recurrent Bell’s palsy
• Diagnosis unclear
• No improvement within 1 month
• Refer to ophthalmology if eye cannot be closed /
cornea remains exposed
Delayed Puberty
• Boys: >14 with testicular volume<4ml
• Girls: >13 without breast development, >15 without
menarche
• Up to 90% cases caused by constitutional delay
• Other causes include:
– Chronic illness or malnutrition
– Excessive exercise, anorexia, deprivation
– Chromosome irregularities - Klinefelter’s, Kalmann’s,
– Irradiation, trauma, drugs
• Congenital adrenal hyperplasia – excess androgens
• Delayed puberty in girls
• Precocious puberty in boys
Catheters
• Emergency admission - indwelling catheter + signs or
symptoms suggesting urosepsis
• Fever,
tachycardia,
hypotension,
confusion,
tachypnoea,
vomiting
• If no signs of urosepsis
• Check position + function of the catheter
• Analgesia with paracetamol / NSAIDS
• Mild symptoms - await urine culture before ABs
• Where empirical antibiotics are indicated
• Trimethoprim 200mg BD for 7 days
• Nitrofurantoin 50mg QDS / 100mg MR BD for 7d
• Reviewed after 48 hrs - assess response + review MCS
Hyperemesis
• Severe / prolonged vomiting with weight loss
(5%+), fluid loss or dehydration
• Affects 1-3% of pregnancies
• If untreated, can lead to significant dehydration,
ketosis and electrolyte imbalance
• NICE suggest PUQE score (Pregnancy Unique
Quantification of Emesis) to assess to severity of
nausea and vomiting in pregnancy
• Treatment: antiemetics, complementary therapies
• May need admission / IV hydration if very severe
BPPV Diagnosis / Treatments
• Hallpike / Dix-Hallpike used for diagnosis of
BPPV
• Epley / Semont / Brandt-Daroff used for
treatment
• Doll’s head - performed in an unconscious
patient looking for brain stem damage
• Valsalva - performed by trying to force air
into a closed space – can be used to test
cardiac function, and to clear ears / sinuses
Hypersensitivity Reactions
Type I - immediate type reaction: IgE mediated
• anaphylaxis, acute asthma, hay fever
Type II - cytotoxic type reaction. IgG/IgM monomer
mediated
• drug-induced haemolysis,
ABO incompatibility and
myasthenia gravis.
Type III - immune complex reaction. IgG/IgM multimer
mediated
• serum sickness,
rheumatoid arthritis
Type IV - delayed type reaction. T cell mediated
• contact dermatitis, chronic asthma
Migraine: Acute Management (NICE
)
• 12-17 years old: paracetamol / NSAID
1st line
– If not effective add in nasal triptan
• Adults: Oral triptan + NSAID / oral triptan +
paracetamol
• Aspirin (900mg) an alternative to NSAIDs
• Consider adding anti-emetic e.g. Prochlorperazine /
domperidone / metoclopramide
• Opiates / ergots not recommended
• Aspirin not suitable for under 16s
• Metoclopramide not recommended for adolescents
Hypoglycaemia Treatment
• 15-20g short-acting carbohydrate if
conscious
• This is equivalent to:
• 3 glucose tablets
• 5 sweets
• 1 small carton of pure fruit juice
• 1 small glass of a sugary drink
• Biscuits and milk contain longer-acting
carbohydrates
• Recheck blood glucose in 15 – 20 minutes
Alcoholic Liver Disease
• Decompensated liver disease may present with
mild ascites and clinically visible jaundice.
• Liver cirrhosis causes the liver to decrease in size
(whereas liver cancer typically causes
hepatomegaly)
• Bloods – AST > ALT – alcohol / advanced cirrhosis
• ALT > AST – hepatitis
• Anti-mitochondrial antibodies - primary biliary
cirrhosis
• Wilson’s disease – copper / caeruloplasmin
Pneumothorax
• Spontaneous (usually in otherwise healthy young
adults)
• Secondary pneumothorax with other lung
conditions:
• COPD
• TB / Sarcoidosis
• CF
• Lung cancer
• Idiopathic pulmonary fibrosis (IPF)
• After trauma
• Hyperresonance on percussion
Weil’s Disease
• Caused by Leptospira interrogans and often
spread by contact with infected rat or cattle urine
• Can occur via contaminated ponds / rivers / lakes
• Incubation 2-21 days
• Presents with abrupt fever, myalgia and cough
• May also have chest pain / haemoptysis
• Activities near / in freshwater increase risk:
• Swimming
• Fishing
• Sailing / canoeing / water skiing
Rectal Investigations
• Haemorrhoids – bright red PR bleeding
• Examination should include DRE
• Initial test – proctoscopy
• If bleeding dark-red / malaena / associated with
change in bowel habit, then colonoscopy indicated
• Flexible sigmoidoscopy – just looks at lower part
of colon – sedation not usually needed
• Barium enema – not reliable for diagnosis of rectal
pathology
• Transrectal ultrasound – usually used to look at
prostate gland!
GORD
• Urgent endoscopy indicated with red flags
• Appetite / weight loss
• Dysphagia / Haematemesis / Malaena
• Epigastric mass
• Consider routine endoscopy if aged 55+ / iron
deficiency anaemia
• Otherwise, if lifestyle changes fail, either:
• Test for Helicobacter pylori (PPI free for 2 weeks)
OR
• Prescribe a full-dose proton pump inhibitor (PPI) for
1 month e.g. omeprazole 20 - 40 mg OD,
lansoprazole 30mg OD
Legionnaires Disease
• Caused by Legionella species
• Spread via AC systems, spas, and hot
water tanks
• 1st line antibtiotics are macrolides
(azithromycin, clarithromycin) or
quinolones (ciprofloxacin)
• In severe legionella, Rifampicin added for
the first few days
Eye Swellings
- • Blepharitis– inflammation of the eyelids
• May be infected (staph.) or associated with seborrhoeic
dermatitis
2.• Conjunctivitis– redness of the eye, usually with
discharge
• Can be allergic, viral, bacterial
3.• Stye – red, very painful lump from base of eyelash
or under the eyelid
• Usually caused by infection
4 • Chalazion – firm lump on the eyelid due to clogged
oil gland.
Usually non-tender (may have mild
tenderness).
If large, can affect vision
Erectile Dysfunction
• Causes can be organic or psychogenic
• Organic causes include:
• Vascular (hypertension),
alcohol,
diabetes,
neurological e.g. MS, post-surgery,
(HAM)
hormonal e.g.hypogonadism,
anatomical e.g. Peyronie’s,
medication related e.g. beta blockers,
antidepressants
• All patients should have BP, examination of
genitalia, lipids, glucose and testosterone levels
• Only patients with LUTS recommended to have
PSA
Acromegaly
• Excess GH levels, usually from pituitary
adenoma
• Increased size of hands / feet / face
• GH level / IGF-1 levels for screening
• OGTT + GH measurement for diagnosis
• MRI head to assess size / location of
pituitary tumour – headaches may be
present if large