Madi Flashcards

1
Q

Polycystic Ovary Syndrome

A

• Oestrogen– can be high or normal

• Total testosterone – can be high or normal
– If >5nmol/L exclude androgen secreting
tumours and CAH

• LH – may be elevated, 3:1 FSH

• FSH – mostly normal

– If LH and FSH both raised consider premature
ovarian insufficiency

– If LH and FSH both reduced consider
hypogonadotropic hypogonadism

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2
Q

Urine Output

A

• Normal urine output:
– Adult: >0.5 ml/kg/h
– Child: >1 ml/kg/h
– Infant: >2 ml/kg/h

• Measured over 6+ hrs e.g. where catheter in situ

• Other diagnostic criteria for AKI
– ↑ in serum creatinine of 26mmol/L in 48 hrs
– 50% ↑ in serum creatinine in 7 days

• Suspend nephrotoxic medication
• Ensure adequate fluid balance
• Monitor renal function + urine output

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3
Q

DVT Management

A

• If Well’s score 2+, refer for proximal leg
vein ultrasound to be done within 4 hours

• If not possible – D-dimer test if +ve:

• Give an interim anticoagulant and arrange
USS doppler within 24 hours

• Apixaban or rivaroxaban 1st line

• If DOAC not suitable
• LMWH for at least 5 days, followed by
dabigatran or edoxaban OR

• LMWH + vitamin K antagonist for 5+ days

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4
Q

Chronic Myeloid Leukaemia

A

• Rare in children
• Accounts for 15% of leukaemia

• Typically chronic insidious onset
• ~30% diagnosed incidentally

• Mean survival 5 – 6 years

• Philadelphia chromosome present in 80%
– Translocation of long arm of chromosome 9
onto long arm of chromosome 22

– Absence of Philadelphia chromosome
indicates worse prognosis

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5
Q

eGFR calculation

A

• eGFR creatinine – normal: 100ml/min/1.73m2
• Derived using CKD-EPI or MDRD equation

• Less accurate where:
• Muscle mass v. abnormal
• Age <18 or >75
• Pregnancy
• Severe malnutrition or obesity
• Rapidly changing kidney function e.g. AKI
• Vegetarian diet

• More accurate test in these groups: Cystatin C
based eGFR

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6
Q

Nutrition

A

• Consider enteral tube feeding if

– Malnourished / at risk of malnutrition +
– Inadequate / unsafe oral intake +
– Functional + accessible GI tract

• (PEG) tube –long term use (4+ weeks)

• Duodenal / jejunal tube – upper GI dysfunction /
inaccessible upper GI tract

• NG tube – acute setting, shorter term. E.g. post
stroke – 2-4 week trial

• TPN – non-functional / inaccessible / perforated
GI tract

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7
Q

Assessing consciousness: GCS

• Assess 3 domains: motor, verbal, eye
opening (MoVE)
• Motor = 1-6
• Verbal = 1-5
• Eye opening =1-4
• Max score = 15 (normal), Min = 3 (dead)

• 13-14 = mild head injury / loss of conc.
• 12 or less should always be scanned

A

Best motor response (M) - There are 6 grades starting with the most severe:
1. No motor response
2. Extension to pain
3. Abnormal flexion to pain
4. Flexion/Withdrawal to pain
5. Localises to pain
6. Obeys commands

Best verbal response (V) - There are 5 grades starting with the most severe:
1. No verbal response
2. Incomprehensible sounds (Moaning but no words.)
3. Inappropriate words
4. Confused
5. Oriented

Best eye response (E) - There are 4 grades starting with the most severe:
1. No eye opening
2. Eye opening in response to pain
3. Eye opening to speech
4. Eyes opening spontaneously

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8
Q

Bell’s Palsy

A

• Acute, unilateral, idiopathic, facial nerve paralysis
• Most make a full recovery within 9 months

• If present within 72 hours, prednisolone can improve
recovery

• Refer to ENT if
• Bilateral Bell’s palsy
• Recurrent Bell’s palsy
• Diagnosis unclear
• No improvement within 1 month

• Refer to ophthalmology if eye cannot be closed /
cornea remains exposed

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9
Q

Delayed Puberty

A

• Boys: >14 with testicular volume<4ml
• Girls: >13 without breast development, >15 without
menarche

• Up to 90% cases caused by constitutional delay
• Other causes include:

– Chronic illness or malnutrition
– Excessive exercise, anorexia, deprivation

– Chromosome irregularities - Klinefelter’s, Kalmann’s,
– Irradiation, trauma, drugs

• Congenital adrenal hyperplasia – excess androgens
• Delayed puberty in girls
• Precocious puberty in boys

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10
Q

Catheters

A

• Emergency admission - indwelling catheter + signs or
symptoms suggesting urosepsis

• Fever,
tachycardia,
hypotension,
confusion,
tachypnoea,
vomiting

• If no signs of urosepsis
• Check position + function of the catheter
• Analgesia with paracetamol / NSAIDS
• Mild symptoms - await urine culture before ABs

• Where empirical antibiotics are indicated
• Trimethoprim 200mg BD for 7 days
• Nitrofurantoin 50mg QDS / 100mg MR BD for 7d

• Reviewed after 48 hrs - assess response + review MCS

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11
Q

Hyperemesis

A

• Severe / prolonged vomiting with weight loss

(5%+), fluid loss or dehydration
• Affects 1-3% of pregnancies

• If untreated, can lead to significant dehydration,
ketosis and electrolyte imbalance

• NICE suggest PUQE score (Pregnancy Unique
Quantification of Emesis) to assess to severity of
nausea and vomiting in pregnancy

• Treatment: antiemetics, complementary therapies
• May need admission / IV hydration if very severe

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12
Q

BPPV Diagnosis / Treatments

A

• Hallpike / Dix-Hallpike used for diagnosis of
BPPV
• Epley / Semont / Brandt-Daroff used for
treatment

• Doll’s head - performed in an unconscious
patient looking for brain stem damage

• Valsalva - performed by trying to force air
into a closed space – can be used to test
cardiac function, and to clear ears / sinuses

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13
Q

Hypersensitivity Reactions

A

Type I - immediate type reaction: IgE mediated
• anaphylaxis, acute asthma, hay fever

Type II - cytotoxic type reaction. IgG/IgM monomer
mediated
• drug-induced haemolysis,
ABO incompatibility and
myasthenia gravis.

Type III - immune complex reaction. IgG/IgM multimer
mediated
• serum sickness,
rheumatoid arthritis

Type IV - delayed type reaction. T cell mediated
• contact dermatitis, chronic asthma

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14
Q

Migraine: Acute Management (NICE

A

)
• 12-17 years old: paracetamol / NSAID

1st line
– If not effective add in nasal triptan

• Adults: Oral triptan + NSAID / oral triptan +
paracetamol

• Aspirin (900mg) an alternative to NSAIDs

• Consider adding anti-emetic e.g. Prochlorperazine /
domperidone / metoclopramide

• Opiates / ergots not recommended

• Aspirin not suitable for under 16s
• Metoclopramide not recommended for adolescents

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15
Q

Hypoglycaemia Treatment

A

• 15-20g short-acting carbohydrate if
conscious

• This is equivalent to:
• 3 glucose tablets
• 5 sweets
• 1 small carton of pure fruit juice
• 1 small glass of a sugary drink

• Biscuits and milk contain longer-acting
carbohydrates

• Recheck blood glucose in 15 – 20 minutes

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16
Q

Alcoholic Liver Disease

A

• Decompensated liver disease may present with
mild ascites and clinically visible jaundice.

• Liver cirrhosis causes the liver to decrease in size
(whereas liver cancer typically causes
hepatomegaly)

• Bloods – AST > ALT – alcohol / advanced cirrhosis

• ALT > AST – hepatitis

• Anti-mitochondrial antibodies - primary biliary
cirrhosis

• Wilson’s disease – copper / caeruloplasmin

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17
Q

Pneumothorax

A

• Spontaneous (usually in otherwise healthy young
adults)

• Secondary pneumothorax with other lung
conditions:

• COPD
• TB / Sarcoidosis
• CF
• Lung cancer
• Idiopathic pulmonary fibrosis (IPF)
• After trauma

• Hyperresonance on percussion

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18
Q

Weil’s Disease

A

• Caused by Leptospira interrogans and often
spread by contact with infected rat or cattle urine

• Can occur via contaminated ponds / rivers / lakes

• Incubation 2-21 days
• Presents with abrupt fever, myalgia and cough
• May also have chest pain / haemoptysis

• Activities near / in freshwater increase risk:
• Swimming
• Fishing
• Sailing / canoeing / water skiing

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19
Q

Rectal Investigations

A

• Haemorrhoids – bright red PR bleeding

• Examination should include DRE
• Initial test – proctoscopy

• If bleeding dark-red / malaena / associated with
change in bowel habit, then colonoscopy indicated

• Flexible sigmoidoscopy – just looks at lower part
of colon – sedation not usually needed

• Barium enema – not reliable for diagnosis of rectal
pathology

• Transrectal ultrasound – usually used to look at
prostate gland!

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20
Q

GORD

A

• Urgent endoscopy indicated with red flags
• Appetite / weight loss
• Dysphagia / Haematemesis / Malaena
• Epigastric mass

• Consider routine endoscopy if aged 55+ / iron
deficiency anaemia

• Otherwise, if lifestyle changes fail, either:

• Test for Helicobacter pylori (PPI free for 2 weeks)
OR

• Prescribe a full-dose proton pump inhibitor (PPI) for
1 month e.g. omeprazole 20 - 40 mg OD,
lansoprazole 30mg OD

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21
Q

Legionnaires Disease

A

• Caused by Legionella species
• Spread via AC systems, spas, and hot
water tanks

• 1st line antibtiotics are macrolides
(azithromycin, clarithromycin) or
quinolones (ciprofloxacin)

• In severe legionella, Rifampicin added for
the first few days

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22
Q

Eye Swellings

A
  1. • Blepharitis– inflammation of the eyelids
    • May be infected (staph.) or associated with seborrhoeic
    dermatitis

2.• Conjunctivitis– redness of the eye, usually with
discharge
• Can be allergic, viral, bacterial

3.• Stye – red, very painful lump from base of eyelash
or under the eyelid
• Usually caused by infection

4 • Chalazion – firm lump on the eyelid due to clogged
oil gland.
Usually non-tender (may have mild
tenderness).
If large, can affect vision

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23
Q

Erectile Dysfunction

A

• Causes can be organic or psychogenic

• Organic causes include:
• Vascular (hypertension),
alcohol,
diabetes,

neurological e.g. MS, post-surgery,
(HAM)
hormonal e.g.hypogonadism,
anatomical e.g. Peyronie’s,
medication related e.g. beta blockers,
antidepressants

• All patients should have BP, examination of
genitalia, lipids, glucose and testosterone levels

• Only patients with LUTS recommended to have
PSA

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24
Q

Acromegaly

A

• Excess GH levels, usually from pituitary
adenoma

• Increased size of hands / feet / face

• GH level / IGF-1 levels for screening

• OGTT + GH measurement for diagnosis

• MRI head to assess size / location of
pituitary tumour – headaches may be
present if large

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25
Diverticular Disease
• Diverticulosis - weaknesses in the bowel wall lead to the formation of small (usually 5 to 10mm) pouches in the wall of the colon • More common with age - asymptomatic • Diverticulitis = inflamed / infected diverticula • Exam findings include: • Tachycardia, fever, abdominal tenderness, guarding and rebound tenderness, and presence of a palpable mass (left sided) • Treatment usually with IV antibiotics
26
Spirometry
1.• FEV1/FVC ratio >70% / 0.7 = restrictive • Pulmonary fibrosis / oedema / pneumoconiosis • 2. FEV1/FVC ratio <70% / 0.7 = obstructive • COPD / asthma FEV1 % predicted: 80%+ Stage 1 - Mild 50-79% Stage 2 - Moderate 30-49% Stage 3 - Severe <30% Stage 4 – Very Severe • In patients without typical symptoms, alternative diagnoses should be sought.
27
Anterior cruciate ligament (ACL) injuries
• Commonly occur after planting a foot on the ground • ‘’Popping’’ sound may be heard • Swelling immediately is common • Lachman’s test is when the tibia is pulled forward with the knee flexed to 20-30 degrees • Forward movement of more than 2mm is considered positive for an ACL injury
28
Status epilepticus
• Seizure lasting 5+ minutes or 3+ fits in 1hr • Buccal midazolam 10mg • Rectal diazepam 10-20mg • Urgent admission via ambulance if not responding promptly or high risk • Diazepam / midazolam can be repeated 10-15 minutes after its first administration • In hospital, IV lorazepam can be used if resuscitation facilities available and IV access already in place
29
Slipped upper femoral epiphysis (SUFE)
• AKA Slipped Capital Femoral Epiphysis (SCFE) • More common in boys vs. girls • Overweight / obese / tall thin / aged 10-15 • Due to upper femoral epiphysis slipping with respect to the femur in a postero-inferior direction. • Symptoms include pain, stiffness and instability • X-Ray to confirm diagnosis • Surgical treatment to pin slipped head
30
Suspected Bladder Cancer: 2WW
Red flags / indications for urgent referral • Aged 45+: • Unexplained visible haematuria without UTI • Visible haematuria that persists or recurs after successful treatment of UTI • Aged 60+: • unexplained non-visible haematuria and either dysuria OR raised WCC
31
Presbycusis
• Progressive, sensorineural hearing loss that occurs with age • Bilateral and symmetrical • Common after 55 years of age • Gradual loss of cochlea hair cells + degeneration in the cochlea nerve • High frequency perception is lost
32
Hoarse Voice
• Acute laryngitis • Duration <3 weeks, pyrexia, sore throat, pain on speaking points • Smokers are more at risk • May have bilateral erythema of the vocal cords • Laryngeal carcinoma • >4 week history • Smoking, alcohol are risk factors • Voice initially muffled then hoarse • May have dysphagia, otalgia, torticollis, lymphadenopathy or neck masses
33
Hoarse Voice
3 Vocal cord palsy • Causes - idiopathic, post-surgery or secondary to neoplasm • Weak breathy voice (not a harsh voice) • May have a bovine cough • 4 Reinke’s oedema • Collection of fluid in the lamina propria bilaterally of the vocal cords • Secondary to another process i.e. GORD or voice abuse. • Diagnoses by direct visualisation with a fine naso- endoscope.
34
Post-coital Bleeding
• Vaginitis from candida infection may cause post-coital bleeding • Foreign bodies unlikely to cause post- coital bleeding • may cause a waxing and waning pain + discharge • NICE guidelines recommend full pelvic examination including cervical speculum examination for post coital / inter- menstrual bleeding
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Central retinal artery occlusion
• Sudden, painless loss of vision • Pallor of the retina • Reduced direct light response • ‘cherry red spot’ (prominent red fovea) • In 90% acuity is finger counting or worse • Needs urgent ophthalmology opinion
37
Anaemias
• Microcytic – Iron deficiency – Haemoglobinopathies (e.g. thalassaemia) • Normocytic – Anaemia of chronic disease – Bone marrow failure – Acute blood loss • Macrocytic – B12 / folate deficiency – Haemolytic anaemias – Liver disease – Impaired red cell production
38
Colorectal Cancer – FIT / qFIT
• Quantitative faecal immunochemical testing (FIT / qFIT) should be offered in adults: – With an abdominal mass – With a change in bowel habit – With iron-deficiency anaemia – 40+ - unexplained weight loss and abdominal pain – <50 with rectal bleeding and unexplained: • Abdominal pain OR weight loss – 50+ with unexplained rectal bleeding, abdominal pain, or weight loss – 60+ with anaemia even in absence of iron deficiency • Suspected cancer pathway: FIT 10+ micrograms / gram
39
Immunoglobulins
• IgA – 10-15%- protect body surfaces that are exposed to outside foreign substances. • IgG – 75-80% - found in all body fluids. Important in fighting bacterial and viral infections. IgG can cross placenta. • IgM – 5-10% - largest antibody. Found in blood and lymph fluid. First response to an infection. • IgE - found in the lungs, skin, and mucous membranes. Cause the body to react against foreign substances. Often involved in allergic type reactions. • IgD - found in small amounts in the tissues that line the belly or chest. How they work is not clear.
40
Dengue Fever
• Carried by Aedes mosquito • Dengue fever has a biphasic fever – Phase I – 3-6 days then remittance – Phase II – 1-2 days • Classical symptoms include diffuse pain – “bone breaking fever” • Malaria not endemic to Australia
41
CREST syndrome
• AKA limited cutaneous systemic sclerosis • Variant of systemic sclerosis (SS) • Calcinosis • Raynaud’s phenomenon • Esophageal dysmotility • Sclerodactyly • Telangiectasia • Anti centromere antibody >98% specificity
42
Bladder Cancer
• Male : Female ratio 3:1 • Symptoms – Haematuria – painless in early tumours – Dysuria / frequency – Abdominal pain (muscle invasive) – Weight loss • Cystoscopy + biopsy diagnostic
43
Management of Severe Acne
• Severe acne = deep scarring / emotional problems • Combination topical therapies +/- oral lymecycline / doxycycline used 1st line for. moderate to severe acne • Isotretinoin (Roaccutane) effective when not responding to other treatments • Teratogenic (caution with female patients) • Laser not recommended except in trials
44
Cholesteatoma
• Congenital – Often presents in children – Chronic purulent discharge not responding to antibiotics • Acquired – secondary to tear or retraction of ear drum – Surgery – e.g. Grommets – Ear infection with rupture of tympanic membrane • Both types can affect the facial nerve.
45
Lipid Modification
Primary Prevention • Manage other modifiable risk factors • smoking / high blood pressure / obesity • Provide lifestyle and dietary advice • Treat if 10-year CVD risk is >10% • 20mg Atorvastatin daily 1st line Secondary Prevention • Treat all patients with CVD • Past / current history of: • MI / angina / stroke / TIA / PAD • Starting dose is Atorvastatin 80mg daily
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Modes of Inheritance
Autosomal dominant Marfan, achondroplasia, neurofibromatosis, Huntington’s Autosomal recessive Albinism, cystic fibrosis, phenylketonuria, sickle cell anaemia X linked dominant Alport / Rett syndrome, Vit. D resistant rickets, Fragile X X linked recessive DMD, haemophilia, G6PD def., Hunter syndrome, colour blindness Polygenic: Neural tube defects, pyloric stenosis Chromosomal: Trisomy 21, Turners (45XO), Klinefelter’s (47 XXY
48
Pain management: opioid strength
Analgesic Dose Notes Morphine sulphate 10mg Oral - universal opioid Morphine sulphate 5mg IM, SC, IV Oxycodone 6.6mg Suitable where morphine not tolerated Diamorphine 3mg I.M. or subcut. Hydromorphone 2mg PO Codeine, dihydrocodeine, tramadol 100mg Weaker opioids
49
Pain management: Fentanyl Only when pain is stable (72 hr patch)
Pain management: Fentanyl Only when pain is stable (72 hr patch) Morphine Salt daily Equivalent Fentanyl Patch 30mg 12 60mg 25 120mg 50 180mg 75 240mg 100 Half the 24hr oral morphine dose, then find closest patch LOWER than this
50
Pain management: Converting Oral to Parenteral Opioids
Oral Morphine Total 24 hour dosage Morphine (SC, IM, IV) Divide by 2 Diamorphine (SC, IM, IV) Divide by 3 30mg 15mg 10mg 60mg 30mg 20mg 90mg 45mg 30mg 120mg 60mg 40mg 180mg 90mg 60mg
51
Skin Cancers
1.• Basal cell carcinoma – Most common, least aggressive – Pearly border 2 • Squamous cell carcinoma – 2nd most common, can metastasize – Transplant patients high risk – Asymmetrical, Telangectasia / Ulceration 3 • Malignant melanoma – Less common, most aggressive – Asymmetrical, irregular, variegated pigmentation
52
Adrenaline Doses
Cardiac arrest • Adults – 1mg (10ml at 1:10,000) IV • Paediatric – 10 micrograms per kg IV Anaphylaxis – 1:1,000 IM preferred • Adults – 0.5mg / 500 mcg (0.5ml) • Child 12 years+: 0.5mg (0.5ml) • Child 6-12 years: 0.3mg (0.3ml) • Child 6m - 6 years: 0.15mg (0.15ml) • Child <6 months: 0.1-0.15 (0.1-0.15ml)
53
Causes of Hypothyroidism
Primary Hashimoto thyroiditis Idiopathic myxoedema Radioactive iodine therapy Subtotal thyroidectomy Neck irradiation Following acute thyroiditis Cystinosis Iodine deficiency Iodine excess (>6 mg/d) Antithyroid drugs Overt hypothyroidism Secondary Hypothalamic / pituitary dysfunction due to neoplasm Pituitary surgery or irradiation Idiopathic hypopituitarism Sheehan syndrome Dopamine infusion Heatstroke Traumatic brain injury
54
Causes of Hyperthyroidism
• Graves’ disease • Toxic multinodular goitre • Toxic adenoma • Iodide-induced hyperthyroidism • Subacute thyroiditis • Factitious (exogenous) thyroiditis • Neonatal thyrotoxicosis (e.g., mother with Graves disease) • TSH-secreting pituitary tumor • Choriocarcinoma or hydatidiform mole • Struma ovarii • Hyperfunctioning thyroid carcinoma (usually metastatic)
55
Thyroid Conditions – Key Features
• Postpartum thyroiditis – usually within 1 year of childbirth • De Quervain’s thyroiditis – associated with viral infection • Overt hypothyroidism – raised TSH and low T4 • Subclinical hypothyroidism – raised TSH, normal T3/T4 • Secondary hypothyroidism – low T4, normal TSH • Drug induced thyrotoxicosis - low TSH, high T3/T4 • Graves’ disease – very low TSH, high T3 / T4
56
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Drugs that affect thyroid function
• Amiodarone can induce hyper or hypothyroidism • Alemtuzumab (MS drug) can also cause hyperthyroidism • Drugs that can cause hypothyroidism: • Glucocorticoids • Dopamine • Lithium • Interferon
58
Subclinical Hypothyroidism
• Raised TSH with normal T3 / T4 • Patient usually asymptomatic • May have tiredness / weight gain • Can develop a goitre • Most common cause is chronic autoimmune thyroiditis • 2-5% go on to overt hypothyroidism
59
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Classic Childhood Conditions
• Pyloric stenosis – projectile vomiting • Intususseption – sausage shaped mass, red currant jelly stool • Retinoblastoma – absent red reflex (white or pale pupil) • Leukaemias are most common childhood cancers – ALL and AML • ALL most common in childhood and young adulthood with a peak incidence at 4-5 yrs • Symptoms – fatigue, bone / joint pain, fever
61
Reactive Arthritis / Reiter’s Syndrome
• Triad of arthritis, conjunctivitis (or uveitis) and urethritis • Can’t see, can’t pee, can’t bend the knee! • Can be secondary to GI infection or STI • Primary may need treatment • Treat individual components
62
Polyarteritis Nodosa
• First vasculitis described (Kussmaul and Maier) • Necrotising vasculitis affecting medium sized arteries • Non-specific symptoms include malaise, headache, arthralgia • 60% have renal involvement (hypertension) • Diagnostic criteria include: – weight loss >4kg, HBsAg +ve, diastolic BP >90, neuropathy amongst others.
63
Gold Standard tests – Respiratory medicine
• Cystic Fibrosis – sweat test / genetics • PE – Pulmonary angiography – V/Q sensitive but not specific – CTPA not as sensitive / specific • Lung cancer – bronchoscopy / biopsy • Bronchiectasis – High Res. CT Scan • Chest infection – sputum culture
64
Bronchiectasis
• Localised irreversible dilatation of part of the bronchial tree • Triad of symptoms – chronic cough – excess purulent sputum production – repeated infections • Haemoptysis in 50% • CXR findings include peribronchial fibrosis • HRCT scan of the chest is used for diagnosis
65
Chronic Heart Failure Treatment
Chronic Heart Failure Treatment • Loop diuretic – up to 80mg furosemide • Prescribe both an ACE inhibitor and a beta blocker – Only start one heart failure drug at a time • ACE inhibitor first if co-morbid diabetes or fluid overload • Beta blocker first if co-morbid angina
66
Treatments for Psychiatric Illness
• CBT – anxiety, depression, phobias • Antidepressants (SSRI, SNRI, TCA) – depression, anxiety • ECT – severe depression resistant to medication / catatonic patients • Antipsychotics – schizophrenia, psychosis • Lithium – bipolar • Psychodynamic psychotherapy – depression, anxiety, eating disorders, personality disorders, trauma
67
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Diagnostic Investigations
• Cushing’s – Dexamethasone suppression – Cortisol levels alone not diagnostic • Addison’s – Synacthen test – No increase in cortisol with ACTH • Acromegaly – OGTT + GH measurement – Measure GH – no drop with glucose load • Diabetes Insipidus – Water deprivation • Diabetes Mellitus – OGTT, Glucose, HbA1C • Myasthenia Gravis – Tensilon test
69
Atypical Pneumoniae
• Pneumocystis jirovecii (carinii)– HIV / AIDS – Silent breathlessness, dry cough • Legionnaire’s disease - Legionella – prodrome, dry cough, confusion, diarrhoea, hyponatraemia, leucocytosis – A/c, hot water systems, spas • Psittacosis – Chlamydia psittaci – “Bird fancier’s lung” – Systemic prodrome, pneumonitis – Rising titre complement fixing antibody
70
Goodpasture’s Syndrome
• Acute glomerulonephritis and pulmonary alveolar haemorrhage • Goodpasture’s disease is an autoimmune cause of the syndrome • 60 - 80% have both renal and pulmonary disease. • CXR - Patchy consolidation, usually bilateral. • Treatment – plasmapharesis / immune suppression
71
Mycoplasma pneumoniae
• Vague and slow-onset history over a few days or weeks • Fever, headache, dry cough with tracheitic ± pleuritic pain, myalgia, malaise and sore throat. • CXR usually shows single lower lobe affected • Complications include cold agglutinin disease and haemolytic anaemia • Treatment is with macrolides
72
Q Fever
• Caused by Coxiella burnetii • Often transmitted from cattle, sheep, goats • Typically starts with flu like illness • Sudden onset of fever, myalgia, headache • Dry cough +/- pleuritic pain • GI symptoms • Can cause acute respiratory distress syndrome and endocarditis
73
Heart Murmurs Summary
A. Presystolic murmur – Mitral/Tricuspid stenosis B. Mitral/Tricuspid regurgitation C. Aortic ejection murmur D. Pulmonic stenosis (spilling through S2) E. Aortic/Pulm. diastolic murmur F. Mitral stenosis - opening snap G. Mid-diastolic inflow murmur H. Continuous murmur of PDA
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Heart Murmurs When does it occur? - systole or diastole
I. Systolic Murmurs: 1. Aortic stenosis - ejection type 2. Mitral / tricuspid regurgitation - pansystolic 3. Mitral valve prolapse - late systole II. Diastolic Murmurs: 1. Aortic regurgitation - early diastole 2. Mitral stenosis - mid to late diastole
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Orbit bleeding risk score Pts with AF 4 to 7 high risk 0-2 low risk 3 medium risk
Male hb less than 130g (120)per litre or heamatocrit less than 40(36) Score 2 (Values for female) Personal history of bleeding : gi ,ic bleed ,hemorrhagic stroke Score 2 Age greater than 74 EGFR less than 60 On antiplatelet Score 1
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First Rank Symptoms
A. Auditory hallucinations B. Broadcasting of thoughts C. Controlled thoughts D. Delusional perception
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Suspected DVT – Well’s Score
• 1 point for each of: • Active cancer • Paralysis, paresis, or recent plaster immobilization • Recently bedridden for 3+ days, or major surgery <12wks • Localized tenderness along the distribution of the deep venous system (such as the back of the calf) • Entire leg is swollen • Calf swelling >3 cm compared with other leg • Pitting oedema confined to the symptomatic leg • Collateral superficial veins (non-varicose) • Previously documented DVT • Score ≤1: DVT unlikely Score 2+: DVT more likely
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Folic Acid
• Reduces incidence of neural tube defects • Recommended before conception – 12 wks • Low risk patients: 400 mcg daily • High risk patients: 5mg daily – BMI 30 kg/m2 + – Previous neural tube defect / FH of NTD – On antiepileptic medication – Diabetes – Sickle-cell disease or thalassaemia (take folic acid throughout pregnancy)
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Risk / Symptom Scores
Scoring Tool Indication / Usage CHA2DS2-VASc Stroke risk in AF ORBIT Bleeding risk in AF – current NICE recommended score HASBLED Bleeding risk in AF – less accurate ABCD2 Stroke risk in TIA QRISK CVD risk
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Gout Diagnosis: NICE 2022
• Suspect gout if typical features: – Rapid onset severe pain, redness, swelling in 1st MTP joint(s) – Tophi • Consider gout if rapid onset of symptoms in other joints • Assess differentials – septic arthritis, pseudogout, inflammatory arthritis • 1st line investigation – serum urate – If level is <360 micromol/litre with typical symptoms repeat at least 2 weeks after flare has settled • 2nd line investigation – synovial fluid microscopy
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Tetralogy of Fallot
• 4 defects – usually present at birth – pulmonary stenosis – ventricular septal defect – right ventricular hypertrophy – an overriding aorta • May have bluish colouration, dyspnoea • Normal size heart – concavity in area of main pulmonary artery – boot shaped
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UTI / Pyelonephritis
• Typical features of UTI: – Dysuria, Frequency, Urgency, Changes in urine appearance, Nocturia, Suprapubic discomfort • Infection may spread from bladder to kidneys • Pyelonephritis should be suspected if fever, loin pain, rigors • Patients should be admitted if tachycardic, hypotension, breathless; marked signs of illness, fever over 38°C
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Abdominal Pain
• Ovarian Torsion – severe pelvic pain, nausea, abnormal bleeding, palpable mass • AAA – can lead to referred flank pain, rare • Appendicitis – right iliac fossa, unlikely to present with pain on left • Sigmoid diverticulitis – unlikely in this age range
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Hypokalaemia
• Serum potassium level < 3.5mmol/L. • Causes: – diuretics, diarrhoea and vomiting, Cushing’s disease, Conn’s syndrome, pyloric stenosis, rectal villous adenoma and renal tubular failure. • Symptoms and signs: – muscle weakness, hypotonia, hyporeflexia, cramps, palpitations and constipation.
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Electrolyte Deficiency
Electrolyte Deficiency • Hyperkalaemia – more common in men, AKI or CKD, medications • Hypokalaemia – more common in women, result of loss of GI fluids (vomiting) • Hypernatremia – most common is hospital setting, associated with IV fluids • Hypercalcaemia – most frequently encountered in malignancy • Hypocalcaemia – common in ICU patients
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Rifampicin Side Effects
• Common / Very common – Nausea, thrombocytopenia, vomiting • Uncommon – Diarrhoea, leukopenia • Unknown frequency – Includes: AKI, Hepatitis, Influenza, Discolouration of sputum, sweat, tears, urine, SCARS • When used IV – Bone pain, GI disorder, hyperbilirubinaemia
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Choking
• Assess severity of obstruction – Mild – breathing, effective cough, speech – Severe – unable to breath / speak, wheezy breath sounds, cyanosis • Mild obstruction – encourage cough • Severe obstruction, conscious – back blows, abdominal thrusts • Severe obstruction, unconscious – CPR (even if pulse is present), call ambulance
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Neck Lumps
• Red flag symptoms – dysphagia, voice change, ipsilateral otalgia, epistaxis, sensation of lump in throat • Pulsatile – vascular cause? • Hard / compressible – malignancy? branchial cyst? • Lymphadenopathy – local / general • Swallow test – does lump move? thyroid lump / thyroglossal cyst • Tongue protrusion – thyroglossal cyst moves up
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Nutritional Deficiency
• Vitamin A– night blindness • Vitamin B1 (thiamine) - Beriberi • Vitamin B3 (niacin) – Pellagra • Vitamin B6 (pyridoxine) – peripheral neuropathy, sideroblastic anaemia • Vitamin C (scurvy) - fragile capillaries, poor wound healing, gingivitis, gum bleeding, haematuria, malaise • Vitamin D – muscle weakness, bone pain, fatigue, depression
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Key Antenatal Appointments
• <10 weeks– booking appointment - lifestyle, screening mother, discuss screening of foetus • 11-14 weeks (11+2 - 14+1)– dating scan • 18-20 weeks (18+0-20+6)– anomaly scan • 28 weeks– further screening, vaccinations, 1st anti-D for rhesus –ve women. • 32 weeks– repeat scan for abnormalities in anomaly scan • 36 weeks– checking foetal position, information re: delivery and early parenthood, ECV if NP • 37 weeks– ECV if not nulliparous and breech
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External Cephalic Version
• Manipulations of foetus to cephalic presentation • Success rate ~50% • Usually done at 37 weeks or later – From 36 weeks in nulliparous women • If ECV unsuccessful, very few babies spontaneously turn to cephalic presentation • If successful, unlikely to return to breech • Reduces the chance of needing C-section
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Poisoning: Antidotes
Poison Antidote Paracetamol N-Acetylcysteine Beta blockers Glucagon, atropine Opioids Naloxone Iron Desferrioxamine Ethylene glycol, methanol Fomepizole / ethanol Warfarin Phytomenadione (Vitamin K) Oral poisons (tablets / capsules) Activated charcoal
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Activated Charcoal
l • Binds poisons to reduce absorption • Can be used for most tablets / capsules • NOT to be used for corrosive substances, alcohol, metal salts, cyanide, petroleum • Effective up to ~1 hour • Repeated doses can be give to enhance elimination after absorption for: – Carbamazepine, Dapsone, Phenobarbital, Quinine, Theophylline
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Key Antenatal Appointments
• <10 weeks– booking appointment - lifestyle, screening mother, discuss screening of foetus • 11-14 weeks (11+2 - 14+1)– dating scan • 18-20 weeks (18+0-20+6)– anomaly scan • 28 weeks– further screening, vaccinations, 1st anti-D for rhesus –ve women. • 32 weeks– repeat scan for abnormalities in anomaly scan • 36 weeks– checking foetal position, information re: delivery and early parenthood, ECV if NP • 37 weeks– ECV if not nulliparous and breech
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External Cephalic Version
• Manipulations of foetus to cephalic presentation • Success rate ~50% • Usually done at 37 weeks or later – From 36 weeks in nulliparous women • If ECV unsuccessful, very few babies spontaneously turn to cephalic presentation • If successful, unlikely to return to breech • Reduces the chance of needing C-section
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Urine Microscopy – Pathological
• >2 red cells /mm3 • >10 white cells /mm3 in an unspun sample • Red / white cell casts – suggest glomerular inflammation – Pyelonephritis – Glomerulonephritis – Interstitial nephritis • Granular casts – seen in any chronic kidney disease
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Urine Microscopy – Normal
• Squamous epithelial cells • <2 red cells /mm3 • <10 white cells /mm3 in an unspun sample • Hyaline casts • Crystals – in old or cold urine
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Drug Side Effects
Side Effect Drugs Gynaecomastia Cimetidine, spironolactone, zoladex, finasteride, CCBs Tardive dyskinesia Metoclopramide, antipsychotics Rhabdomyolysis Statins Deafness Gentamycin Erectile Dysfunction Antihypertensives, antidepressants, nicotine Jaundice Nitrofurantoin, erythromycin, isoniazid, methyldopa, indometacin, salicylates
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Ankylosing Spondylitis
• Chronic, painful, degenerative inflammatory arthritis • Primarily affects spine and sacroiliac joints • Eventual fusion of the spine • The 4 ‘A’s of AS are; – anterior uveitis – apical fibrosis – aortic regurgitation – Achilles tendonitis. • Management is medical (NSAIDs, DMARDs, TNF α) or surgical to correct flexion deformities.
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Anaphylaxis Management: Adults
• IM Adrenalin 1:1000 • 500 micrograms / 0.5mg / 0.5ml • IV steroids no longer recommended • Where fluids required, use crystalloids
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Antidepressants
• Individual CBT + anti-depressant recommended in more severe depression (moderate / severe depression) • SSRI 1st line for most patients – optimise dose • Sertraline, citalopram, fluoxetine • 2nd line / 3rd line • Alternate SSRI if no response • TCA or SNRI (avoid if high risk of overdose) • Amitriptyline, Venlafaxine • When changing antidepressants, cross taper or stop 1st drug before starting new drug
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Cardio / Respiratory Tests
• Resting 12 lead ECG – chest pain, HTN, pre-op • ABPM / HBPM - hypertension • Exercise ECG – known CAD + ?stable angina • 24 hour ECG – palpitations, paroxysmal AF • Echocardiogram – suspected heart failure / structural • Spirometry - COPD • Chest X-Ray – pneumonia, lung cancer (initial) • Bronchoscopy – lung cancer • Ultrasound doppler - DVT • CT scan – stroke, lowered GCS
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Activated Charcoal
• Binds poisons to reduce absorption • Can be used for most tablets / capsules • NOT to be used for corrosive substances, alcohol, metal salts, cyanide, petroleum • Effective up to ~1 hour • Repeated doses can be give to enhance elimination after absorption for: – Carbamazepine, Dapsone, Phenobarbital, Quinine, Theophylline
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Post-coital Bleeding
• Vaginitis from candida infection may cause post-coital bleeding • Foreign bodies unlikely to cause post- coital bleeding • may cause a waxing and waning pain + discharge • NICE guidelines recommend full pelvic examination including cervical speculum examination for post coital / inter- menstrual bleeding