Macromolecules Of Interest Flashcards
What a brief overview of collagen
Fibrous protein
Long, stiff triple helical structure
80-90% type 1,2,3
What is a macromolecule
Molecule such as a protein, nucleic a, polysacc
What is the structure of type 1
Long and thin
Triple helix
Three coiled subunits
What are some amino acids associated with collagens
Simplest is glycine which is small a nd can pack into small molecules
Proline is a ring structure has a fixed angle allowing helix formation
Neither made in cell
What does hydroxyproline and hydroxylisine do
HP - fixed angle allows helix form
HL - stabilises side by side packing
What is a molecular chaperone
Monitored folding and if incorrect fix it
Assist correct folding and assemble
What is scelroderma
Rare chronic disease excessive deposits collagen
What is oral sub mucosa fibrosis
Chronic debilitating disease caused by chewing habit increase type 1 and 3 collagen
What is osteogenesis imperfecta
Brittle bones have 6types
Ehlers danlos syndrome
Rare genetic disorder caused by defective collagen giving unstable flexible joints
What is a glycosaminoglycan
Unbranched polysaccharide chains composed of repeating disaccharide units
One sugar - amino sugar
Second sugar- uronic sugar
What is hyaluronan
Non sulphated glycosaminoglycan
Not covalently bound to protein
How is hyaluronan synthesise
Through cell membrane
Bind water molecules
How is collagen sun roughly
Look at post translational modifications just slight diff
What is the enzyme used to synthesise ha
Ha synthase
Adds
2 types of UDP together to = chain
