MABs

Question 1

Pembrolizumab

Answer 1

Blockade of the PD1-PDL1 interaction
Used in refractory metastatic melanoma.

Pembrolizumab, sold under the brand name Keytruda, is a humanized antibody used in cancer immunotherapy that treats melanoma, lung cancer, head and neck cancer, Hodgkin lymphoma, and stomach cancer.

It is an IgG4 isotype antibody that blocks a protective mechanism of cancer cells and thereby, allows the immune system to destroy them. It targets the programmed cell death protein 1 (PD-1) receptor of lymphocytes.

Question 2

Ipilimumab

Answer 2

Blockade of the CTLA-4 pathway

Question 3

Bevacizumab

Answer 3

VEGF inhibitor. Inhibition of tumor neoangiogenesis

Question 4

Rituximab

Answer 4

Anti-CD 20 MAB indicated for non-Hodgkin’s lymphoma

Question 5

Imatinib

Answer 5

Tyrosine kinase inhibitor. Imatinib is specific for the TK domain in abl (the Abelson proto-oncogene), c-kit and PDGF-R (platelet-derived growth factor receptor). Specifically, it is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+), certain types of gastrointestinal stromal tumors (GIST),

Question 6

Vemurafenib

Answer 6

Selective kinase inhibitor used for BRAF mutation in melanoma

Question 7

Dabrafenib

Answer 7

Selective kinase inhibitor used for BRAF mutation in melanoma