MAAM CHA PART 1 HAHAHA Flashcards
A defensive reaction intended to neutralize, control or eliminate offending agent and to prepare the site for repair
Inflammation
What releases blood-clotting proteins at wound site?
Platelets from blood
What secrete factors that mediate vasodilation and vascular constriction, delivery of blood, plasma and cells to injured area increases
Mast cells
What does neutrophils secrete?
Neutrophils secrete factors that kill and degrade pathogens
What are the 5 cardinal signs of inflammation?
- Redness
- Heat
- Swelling
- Pain
- Loss of function
What do you call the process where neutrophils and macrophages remove pathogens?
phagocytosis
What hormone does macrophages secrete?
cytokines
What is the function of cytokines?
Attract immune system cells to the site and activate cells involved in tissue repair
3 chemical substances
- Histamine
- Kinins
- Prostaglandins
What does histamine help with?
Vasodilation and increase capillary permeability
What does kinins help with?
Attract neutrophils
What does prostaglandin help with?
Increase capillary permeability
What are the systemic responses to inflammation?
- Fever
- Pyrogens
- Leukocytosis
- Malaise, loss of appetite, aching, weakness
Occur to provide the body with greater ability to fight infection
Leukocytosis
Types of Inflammation
- Acute
- Chronic
- Subacute
Describe acute inflammation
- Local vascular and exudative changes
- Protective
- 2 weeks healing
Describe chronic inflammation
- Persists, not beneficial, not protective
- Month, years
- Debilitating and long lasting effect
- repair
Describe subacute inflammation
- Between acute and chronic
What proceeds after the inflammatory debris is removed?
Cellular healing
Proliferation of the same type of cells as destroyed
Regeneration
- Cells of another type
- Fill in the tissue defect
- Scar formation
Replacement
3 types of healing by regeneration
- Labile cells
- Permanent cells
- Stable
2 types of healing by replacement
- Primary Intention
- Secondary Intention
It refers to the body’s specific protective response to an invading foreign agent or organism functions as the body’s defense mechanism against invasion
Immunity
Immunity is affected by?
- age
- emotional status
- CNS fxn
- medications
- trauma
- stress
- surgery
Level 1: Barriers
Skin and cilia prevent invaders from entering
Level 2: Innate
Cells and chemicals stop invaders from spreading
Level 3: Adaptive
Blood warriors (with a grudge) attack invaders
What are the components of the immune system?
- Bone Marrow
- Lymphoid Tissue - thymus gland, spleen, lymph nodes, tonsils, adenoids
- Tonsils
- Adenoids
- Mucoid Lymphatic Tissues
2 types of immunity
- Nature (Innate)
- Acquired
An immunity that is born with. Which is nonspecific, provides a broad spectrum of defense against and resistance to infection.
Nature (Innate) Immunity
An immunity that develops after birth
Acquired Immunity
A type of acquired immunity that typically lasts many years or even a lifetime.
Active Acquired Immunity
A type of acquired immunity that is
a temporary immunity transmitted from a source outside the body that has developed immunity through previous disease or immunization.
Passive Acquired Immunity
Produces the antibody after being sick
Active Natural Immunity
Immunization (produce antibodies)
Active Artificial Immunity
Antibodies are given to you by the mother or breastfeeding
Passive Natural Immunity
Antibodies are given by the vaccine
Passive Artificial Immunity
Example of physical barriers
- Skin- first line of defense
- Cilia
- Mucous membranes
- Coughing
- Sneezing
Example of chemical barriers
- Acidic gastric secretion
- Mucus
- Enzymes in tears and saliva substances in
sebaceous and sweat glands - Interferons
Normal values for total WBC
Total WBC: 4,500-10,000
It occurs when the WBC falls below 4,000.
Leukopenia
What causes leukopenia?
- Viral infections
- overwhelming bacterial infections
- bone marrow disorders
A WBC of less than 500 places the patient at?
risk for a fatal infection
A WBC over 30,000 may indicate
Massive infection or a serious disease such as leukemia