M3:U3 Blood Porphobilinogen Bilirubin Urobilinogen

Question 1

Increase in rbc

Answer 1

Hematuria

Question 2

Increase in hemoglobin due to lysis of rbc or prolonged standing

Answer 2

Hemoglobinuria

Question 3

heme containing compounds that are also positive in chemical test

Answer 3

Hemoglobin
myoglobin
intact rbc
cytochrome

Question 4

Porphyrin precursor intermediate compound in heme synthesis

Answer 4

Porphobilinogen

Question 5

Orange yellow pigment formed by heme containing proteins

Answer 5

Bilirubin

Question 6

Colorless compound formed from deconjugation of bilirubin

Answer 6

Urobilinogen

Question 7

20% of urobilinogen are reabsorbed and reduced to

Answer 7

stercobilinogen

Question 8

2% to 5% of urobilinogen

Answer 8

Excreted in urine

Question 9

Hemoglobin is normally bound to ___ in the bloodstream

Answer 9

Haptoglobin

Question 10

When all of haptoglobin has already been bound this can easily pass through the gfb

Answer 10

Free hemoglobin

Question 11

Pathway of free hemoglobin in the kidney

Answer 11

reabsorbed in PCT
catabolized to ferritin by RTC
denatured to hemosiderin
Within 2 to 3 days after hemolytic episode

Question 12

Caused by presence of intravascular hemolysis where rbcs are lysed prior to reaching gfb

Answer 12

True hemoglobinuria

Question 13

Results from rbc lysis in urinary tract or urine due to alkaline or hypotonic urine more common

Answer 13

Pseudo hemoglobinuria

Question 14

Differentiate true hemoglobinuria versus pseudo hemoglobinuria

Answer 14

Presence of hemosiderin granules (tested through prussian blue test)

Question 15

Release due to muscle damage

Answer 15

Myoglobinuria

Question 16

Hemoglobinuria or myoglobinuria:
More toxic to renal tubules

Answer 16

Myoglobinuria

Question 17

Hemoglobinuria or myoglobinuria:
Less toxic to renal tubules

Answer 17

Hemoglobinuria

Question 18

Hemoglobinuria or myoglobinuria:
Red or pink serum color

Answer 18

Hemoglobinuria

Question 19

Hemoglobinuria or myoglobinuria:
Normal pale yellow serum

Answer 19

Myoglobinuria

Question 20

Hemoglobinuria or myoglobinuria:
Decrease to absent haptoglobin

Answer 20

Hemoglobinuria

Question 21

Hemoglobinuria or myoglobinuria:
Normal haptoglobin

Answer 21

Myoglobinuria

Question 22

Hemoglobinuria or myoglobinuria:
Increase creatinine kinase, < 10x upper limit

Answer 22

hemoglobinuria

Question 23

Hemoglobinuria or myoglobinuria:
Increased creatinine kinase, > 10x upper limit

Answer 23

Myoglobinuria

Question 24

Hemoglobinuria or myoglobinuria:
Ammonium sulfate Precipitation test precipitated

Answer 24

Hemoglobinuria

Question 25

Hemoglobinuria or myoglobinuria: Ammonium sulfate precipitation test soluble

Answer 25

Myoglobinuria

Question 26

Also known as ammonium sulfate precipitation test

Answer 26

Blondheim test