M2: anti-biotics, virals, MDR, NSaids Flashcards
23, 24, 25, 49, 50
Factors that place a patient at risk of developing an antimicrobial-resistant organism include:
1. Age over 50 years
2. School attendance
3. Travel within the U.S.
4. Inappropriate use of antimicrobials
- Inappropriate use of antimicrobials
Infants and young children are at higher risk of developing antibiotic-resistant infections due to:
1. Developmental differences in pharmacokinetics of the antibiotics in children
2. The fact that children this age are more likely to be in daycare and exposed topathogens from other children
3. Parents of young children insisting on preventive antibiotics so they don’t miss
work when their child is sick
4. Immunosuppression from the multiple vaccines they receive in the first 2 yearsof life
- The fact that children this age are more likely to be in daycare and exposed topathogens from other children
Providers should use an antibiogram when prescribing. An antibiogram is:
1. The other name for the Centers for Disease Control guidelines for prescribing antibiotics
2. An algorithm used for prescribing antibiotics for certain infections
3. The reference also known as the Pink Book, published by the Centers for Disease Control
4. A chart of the local resistance patterns to antibiotics developed by laboratories
- A chart of the local resistance patterns to antibiotics developed by laboratories
There is often cross-sensitivity and cross-resistance between penicillins and cephalosporins because:
1. Renal excretion is similar in both classes of drugs.
2. When these drug classes are metabolized in the liver they both produce resistant enzymes.
3. Both drug classes contain a beta-lactam ring that is vulnerable to beta-lactamase-producing organisms.
4. There is not an issue with cross-resistance between the penicillins and
cephalosporins.
- Both drug classes contain a beta-lactam ring that is vulnerable to beta-lactamase-producing organisms.
Jonathan has been diagnosed with strep throat and needs a prescription for an antibiotic. He says the last time he had penicillin he developed a red, blotchy rash. An appropriate antibiotic to prescribe would be:
1. Penicillin VK, because his rash does not sound like a serious rash
2. Amoxicillin
3. Cefadroxil (Duricef)
4. Azithromycin
- Azithromycin
Sarah is a 25-year-old female who is 8 weeks pregnant and has a urinary tract infection. What would be the appropriate antibiotic to prescribe for her?
1. Ciprofloxacin (Cipro)
2. Amoxicillin (Trimox)
3. Doxycycline
4. Trimethoprim-sulfamethoxazole (Septra)
- Amoxicillin (Trimox)
Pong-tai is a 12-month-old child who is being treated with amoxicillin for acute otitis media. His parents call the clinic and say he has developed diarrhea. The appropriate action would be to:
1. Advise the parents that some diarrhea is normal with amoxicillin and recommend probiotics daily.
2. Change the antibiotic to one that is less of a gastrointestinal irritant.
3. Order stool cultures for suspected viral pathogens not treated by the amoxicillin.
4. Recommend increased fluids and fiber in his diet.
- Advise the parents that some diarrhea is normal with amoxicillin and recommend probiotics daily.
Lauren is a 13-year-old child who comes to clinic with a 4-day history of cough, low-grade fever, and rhinorrhea. When she blows her nose or coughs the mucous is greenish-yellow. The
appropriate antibiotic to prescribe would be:
1. Amoxicillin
2. Amoxicillin/clavulanate
3. TMP/SMZ (Septra)
4. None
- None
Joanna had a small ventricle septal defect (VSD) repaired when she was 3 years old and has no residual cardiac problems. She is now 28 and is requesting prophylactic antibiotics for an upcoming dental visit. The appropriate antibiotic to prescribe according to current American
College of Cardiology and American Heart Association guidelines is:
1. None, no antibiotic is required for dental procedures
2. Amoxicillin 2 grams 1 hour before the procedure
3. Ampicillin 2 grams IM or IV 30 minutes before the procedure
4. Azithromycin 1 gram 1 hour before the procedure
- None, no antibiotic is required for dental procedures
Fluoroquinolones have a Black Box Warning regarding even months after treatment.
1. Renal dysfunction
2. Hepatic toxicity
3. Tendon rupture
4. Development of glaucoma
- Tendon rupture
To prevent further development of antibacterial resistance it is recommended that fluoroquinolones
be reserved for treatment of:
1. Urinary tract infections in young women
2. Upper respiratory infections in adults
3. Skin and soft tissue infections in adults
4. Community-acquired pneumonia in patients with comorbidities
- Community-acquired pneumonia in patients with comorbidities
Janet was recently treated with clindamycin for an infection. She calls the advice nurse because she is having frequent diarrhea that she thinks may have blood in it. What would be the appropriate care for her?
1. Encourage increased fluids and fiber.
2. Assess her for pseudomembranous colitis.
3. Advise her to eat yogurt daily to help restore her gut bacteria.
4. Start her on an antidiarrheal medication.
- Assess her for pseudomembranous colitis.
Jamie has glucose-6-phosphate dehydrogenase deficiency (G6PD) and requires an antibiotic. Which class of antibiotics should be avoided in this patient?
1. Penicillins
2. Macrolides
3. Cephalosporins
4. Sulfonamides
- Sulfonamides
Keng has chronic hepatitis that has led to mildly impaired liver function. He has an infection that would be best treated by a macrolide. Which would be the best choice for a patient with liver
dysfunction? If renal fxn not impaired
1. Azithromycin (Zithromax)
2. Clarithromycin (Biaxin)
3. Erythromycin (E-mycin)
4. None of the above
test bank-erythromyacin
Quiz 2: Biaxin
If a patient is allergic to sulfonamide antibiotics, he or she will most likely have cross-sensitivity to:
1. Loop diuretics
2. Sulfonylureas
3. Thiazide diuretics
4. All of the above
- All of the above
Tetracyclines such as minocycline are safe to use in:
1. Pregnant women
2. Adolescents
3. Patients with renal dysfunction
4. Patients with hepatic dysfunction
- Adolescents
Tetracyclines should not be prescribed to children younger than 8 years due to:
1. Risk of developing cartilage problems
2. Development of significant diarrhea
3. Risk of kernicterus
4. Adverse effects on bone growth
- Adverse effects on bone growth
Nicole is a 16-year-old female who is taking minocycline for acne. She comes to the
clinic complaining of a headache. What would be the plan of care?
1. Advise acetaminophen or ibuprofen as needed for headaches.
2. Prescribe sumatriptan (Imitrex) to be taken at the onset of the headache.
3. Evaluate her for pseudotremor cerebri.
4. Assess her caffeine intake and sleep patterns
- Evaluate her for pseudotremor cerebri.
Patricia has been prescribed doxycycline for a chlamydia infection. She is healthy and her only medication is an oral combined contraceptive. Patricia’s education would include:
1. Use a back-up method of birth control (condom) until her next menses.
2. Doxycycline may cause tendonitis and she should report any joint pain.
3. Her partner will need treatment if her infection doesn’t clear with the doxycycline.
4. Doxycycline is used for one-dose treatment of STIs; take the whole prescription
at once
- Use a back-up method of birth control (condom) until her next menses.
To prevent the development of peripheral neuropathy in patients taking isoniazid for tuberculosis the patient is also prescribed:
1. Niacin (vitamin B3)
2. Pyridoxine (vitamin B6)
3. Riboflavin (vitamin B2)
4. Thiamine (vitamin B1)
- Pyridoxine (vitamin B6)
Sadie is an 82-year-old patient who has herpes zoster (shingles) and would benefit from an antiviral such as valacyclovir. Prior to prescribing valacyclovir she will need an assessment of:
1. Complete blood count to rule out anemia
2. Liver function
3. Renal function
4. Immunocompetence
- Renal function
When prescribing acyclovir, patients should be educated regarding the:
1. High risk of developing diarrhea
2. Need to drink lots of fluids during treatment
3. Risk for life-threatening rash such as Stevens-Johnson
4. Eccentric dosing schedule
- Need to drink lots of fluids during treatment
Nicholas has been diagnosed with type A influenza. Appropriate prescribing of
oseltamivir (Tamiflu) would include:
1. Starting oseltamivir within the first 48 hours of influenza symptoms
2. Advising the patient he can stop the oseltamivir when his symptoms resolve
3. Educating the patient that oseltamivir will cure influenza
4. Prophylactic treatment of all family members
- Starting oseltamivir within the first 48 hours of influenza symptoms
Monitoring for patients who are on long-term antifungal therapy with ketoconazole includes:
1. Platelet count
2. BUN and creatinine
3. White blood cell count
4. AST, ALT, alkaline phosphatase, and bilirubin
- AST, ALT, alkaline phosphatase, and bilirubin
When prescribing metronidazole (Flagyl) to treat bacterial vaginosis, patient education would include:
1. Metronidazole is safe in the first trimester of pregnancy.
2. Consuming alcohol in any form may cause a severe reaction.
3. Sexual partners need concurrent therapy.
4. Headaches are a sign of a serious adverse reaction and need immediate evaluation
- Consuming alcohol in any form may cause a severe reaction.
Every antibiotic drug class has resistant organisms that influence prescribing decisions.
1. True
2. False
True
Which person should be treated with prophylactic antitubercular medication?
1. A child who attends the same school with a child who has tuberculosis
2. A nurse who is working in a hospital
3. An individual who is HIV-positive with a negative TB skin test
4. A patient who has close contact with someone who has
tuberculosis
ANS: 4
Personal contact with a person having a diagnosis of tuberculosis is required to indicate prophylactic treatment
with antitubercular therapy. Attending the same school does not necessarily mean close contact occurs. Health
care professionals do not need prophylactic treatment. HIV-positive individuals with negative TB skin tests do not need prophylaxis.
A patient who has chronic liver disease reports contact with a person who has tuberculosis (TB). The
nurse will counsel this patient to contact the provider to discuss
1. a chest x-ray.
2. a TB skin test.
3. liver function tests (LFTs).
4. prophylactic
antitubercular drugs.
ANS: 2
Patients who have exposure to TB should have a TB skin test. A chest x-ray is performed if the skin test is
positive. LFTs do not need to be done simply because of TB exposure. This patient is not a candidate for
antitubercular drug prophylaxis
A patient who has tuberculosis asks the nurse why three drugs are used to treat this disease. The nurse will explain that multi-drug therapy is used to reduce the likelihood of
1. disease relapse.
2. drug hypersensitivity reactions.
3. drug resistance.
4. drug adverse effects.
ANS: 3
Without multi-drug therapy, patients easily develop resistance to antitubercular drugs. Using more than one antitubercular drug does not prevent relapse, hypersensitivity reactions, or adverse effects.
The nurse is caring for a patient who is diagnosed with tuberculosis. The patient tells the nurse that the provider plans to order a prophylactic antitubercular drug for family members and asks which drug will be ordered. The nurse will expect the provider to order which drug?
1. Isoniazid (INH)
2. Pyrazinamide
3. Rifampin (Rifadin)
4. Streptomycin
ANS: 1
INH is the drug of choice for prophylactic treatment of patients who have had close contact with a patient who has tuberculosis.
A patient is being treated with isoniazid (INH), rifampin, and pyrazinamide in phase I of treatment for tuberculosis. The organism develops resistance to isoniazid. Which drug will the nurse anticipate the provider will
order to replace the isoniazid?
1. Ciprofloxacin (Cipro)
2. Ethambutol (Myambutol)
3. Kanamycin
4. Streptomycin sulfate
ANS: 2
If there is bacterial resistance to isoniazid, the first phase may be changed to ethambutol, rifampin, and
pyrazinamide. Ciprofloxacin, kanamycin, and streptomycin are not generally first-line antitubercular drugs.
The nurse is teaching a patient about rifampin. Which statement by the patient indicates understanding of the teaching?
1. I should not wear soft contact lenses while taking rifampin.
2. I will need regular eye examinations while taking this drug.
3. I will report orange urine to my provider immediately.
4. I understand that renal toxicity is a common adverse effect.
ANS: 1
Patients taking rifampin should be warned that urine, feces, saliva, sputum, sweat, and tears may turn a harmless
red-orange color. Patients should not wear soft contact lenses to avoid permanent staining. Regular eye exams
are necessary for patients who receive isoniazid and ethambutol. Orange urine is a harmless side effect and does
not need to be reported. Renal toxicity is not common with rifampin.
A patient who is taking isoniazid (INH) as part of a two-drug tuberculosis treatment regimen reports tingling of the fingers and toes. The nurse will recommend discussing which treatment with the provider?
1. Adding pyrazinamide
2. Changing to ethambutol
3. Increasing oral fluid intake
4. Taking pyridoxine (B6)
ANS: 4
Peripheral neuropathy is an adverse reaction to INH, so pyridoxine is usually given to prevent this. It is not
necessary to change medications. Increasing fluids will not help with this.
The nurse caring for a patient who has tuberculosis and who is taking isoniazid, rifampin, and streptomycin reviews the medical record and notes the patients sputum cultures reveal resistance to
streptomycin. The nurse will anticipate that the provider will take which action?
1. Add ethambutol (Myambutol).
2. Change the streptomycin to clarithromycin.
3. Change the streptomycin to kanamycin.
4. Order renal function tests.
ANS: 3
The patients current regimen is first-phase treatment. If resistance to streptomycin develops, the provider can
change to kanamycin or to ciprofloxacin. Ethambutol is added if there is resistance to isoniazid. Clarithromycin is
used during phase II. Renal function tests are not indicated.
A patient who has oral candidiasis will begin using nystatin suspension to treat the infection. What information will the nurse include when teaching this patient?
1. Coat the buccal mucosa with the drug and then rinse your mouth.
2. Gargle with the nystatin and then spit it out without swallowing.
3. Mix the suspension with 4 ounces of water and then drink it.
4. Swish the liquid in your mouth and then swallow after a
few minutes.
ANS: 4
Patients should be taught to swish the suspension in the mouth to coat the tongue and buccal mucosa and then
swallow the medication. It should not be spit out, diluted with water, or swallowed with water
A patient who has completed the first phase of a three-drug regimen for tuberculosis has a positive sputum acid- bacilli test. The nurse will tell the patient that
1. drug resistance has probably occurred.
2. it may be another month before this test is negative.
3. the provider will change the pyrazinamide to ethambutol.
4. there may be a need to remain in the first phase of therapy for several weeks.
ANS: 2
The goal is for the patients sputum test to be negative 2 to 3 months after the therapy. The positive test does not
indicate drug resistance. The provider will not change the drugs or keep the patient in the first phase longer than
planned.