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PHARMACOLOGY > M2: Adrenoreceptor Antagonist Drugs > Flashcards

M2: Adrenoreceptor Antagonist Drugs Flashcards

0
Q

Reversible agonist

A

Phentolamin & Prazosin

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1
Q

May be reversible or irreversible

A

Alpha receptor antagonism

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2
Q

Irreversible antagonist

A

Phenoxybenzamine

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3
Q

Dec peripheral vascular resistance leads to orthostatic hypotension and reflex tachycardia. Miosis. Nasal stuffiness. Dec resistance to urine outflow.

A

Alpha 1 receptor antagonist

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4
Q

Irreversible A1 antagonist. Inhibition of NE uptake. Blocks sero, acetyl & etc. Attenuation and potentiation of catecholamine induced vasoconstriction. Treatment for pheochromocytoma. Given per orem.

A

Phenoxybenzamine

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5
Q

Diagnosis for Pheochromocytoma

A

Measure VMA & Ultz

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6
Q

Metabolic product of catecholamine breakdown

A

VMA

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7
Q

Orthostatic hypo, tachy, nasal stuffiness, inhibition of ejaculation.

A

SE & AE of phenoxybenzamine

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8
Q

Competitive antagonist of A1 & A2 receptors. Dec peripheral vascular resistance. For pheochromocytoma

A

Phenotalamine

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9
Q

Highly selective for A1 receptors. Relaxation of arterial & venule smooth muscle . For BPH. Relaxation of prostate muscle. Mgt for HPN

A

Prazosin/Minipress

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10
Q

Reversible A1 antagonist. For HPN & BPH. Extensively metabolized in the liver. Not usually used for HPN.

A

Terazosin

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11
Q

Half life is 22hrs. Longer. For HPN & BPH.

A

Doxazosin

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12
Q

A1 antagonist. High bioavailability. Inhibition of contractions in prostate smooth muscles. Less effect on standing BP.

A

Tamsulosin

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13
Q

Hypersecretion of catecholamines. Hypertension, headache, palpitation & excessive sweating.

A

Pheochromocytoma

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14
Q

Mild to moderate systemic HPN. Major adverse effect is orthostatic hypotension.

A

Chronic HPN

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15
Q

Peripheral Vascular Dse: Ar blocking agents are not effective. For reynauds phenomenon

A

Prazosin & Phenyoxybenzamine

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16
Q

Urinary Obstruction

A

Prazisin, Doxasozine, Terazosin& tamsulosin

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17
Q

Beta blockers: good oral absorption. Peak plasma concentration

A

1-3hrs after ingestion

18
Q

Extensive first pass effect among BetaB. Low bioavailability. Noncardio selective. Notorious for asthma attacks. For hyperthyroidism.

A

Propanolol

19
Q

BetaB that Cross the BB

A

Propanolol & Penbutolol

20
Q

Half life is 10mins

A

Esmolol

21
Q

Longest half life of 24hrs

A

Nadolol

22
Q

Lower BO via (-) inotropic & chronotropic effects. Increas peripheral resistance.

A

BetaB

23
Q

BetaB: _______ in airway resistance as a result of ______.

A

Inc. Bronchoconstriction.

24
Q

BetaB: in eye. Dec prod of ________ in px with glaucoma. Dec IOP.

A

Aqueous humor

25
Q

BetaB: metabolism. Inhibition of

A

Lypolysis & Glycogenolysis

26
Q

BetaB: metabolism. Inc _____

A

Vldl

27
Q

Prototype BetaB. Low bioavailability. Use for HPN, angina, dysrhythmia & hyperthyroidism.

A

Propanolol

28
Q

Beta1 selective. Safer in px who experience bronchoconstriction and COPD

A

Metoprolol

29
Q

Highly selective B1 blocker. Elicit vasodilation. Good for CHF.

A

Nevibolol

30
Q

Long duration. Spectrum similar to timolol.

A

Nadulol

31
Q

Non selective, ocular hypotensive effects. For patients with glaucoma

A

Timolol

32
Q

Topical opthalmic with glaucoma

A

Levobunolol & Betaxoxol

33
Q

Less likely to produce bradycardia & plasma lipid abnormalities

A

Pindolol, acebutolol, carteolol

34
Q

Potent A & B blocker

A

Labetalol

35
Q

Ultra short acting B1 blocker. Short half life 10mins. Used for SVP, perioperative HPN & antianginal agent

A

Esmolol

36
Q

Hypertension. Effective & well tolerated. Used with a diuretic & vasodilator. Administered once or twice daily.

A

Beta Blockers

37
Q

Used for ischemic heart dse. Dec O2 demand. Improve exercise tolerance and reduce anginal episodes. Improve survival following AMI.

A

Timolol, propanolol & metoprolol

38
Q

Reduce ventricular ectopic beats.

A

Bblockers

39
Q

Reduce mortality in pxs with CHF

A

Metoprolol, Bisoprolol & Carvedilols

40
Q

For local us glaucoma which reduces IOP

A

Timolol

41
Q

Excessive catecholamine action. Inhibition of T3 & T4.

A

Propranolol

42
Q

Used for migraine, somatic manifestations of anxiety & alcohol withdrawal.

A

Propranolol

PHARMACOLOGY (8 decks)

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