M1: Pharmacokinetics

Question 0

Time course of drug in the body. Encompassing absorption, distribution, metabolism & excretion. What body does to the drug. Determine the optimal formulation of a drug, dose & dosing frequency during drug development.

Answer 0

Pharmacokinetics

Question 1

Entry of drug from site of admin to systemic circulation

Answer 1

Absorption

Question 2

Biotransformation

Answer 2

Metabolism

Question 3

Entry of drug to the tissues

Answer 3

Ditribution

Question 4

Mode of exit of drug from the body

Answer 4

Excretion

Question 5

Travel of drug across cellular membranes. Dependent on solubility, surface area, concentration gradient, tissue vascularity & ionization.

Answer 5

Permeability

Question 6

Correlates the ability of a drug to cross cell membrane

Answer 6

Solubility

Question 7

Ability to pass through lipid bilayers

Answer 7

Lipid solubility

Question 8

Pass in aqueous phases

Answer 8

Water solubility

Question 9

Ratio of lipid to aqueous solubility

Answer 9

Partition coefficient

Question 10

The higher the partition coefficient, the more the ______ the drug.

Answer 10

Soluble

Question 11

Determines the percentage of ionization. Drugs are either weak acids or weak bases & can exist as charged or neutral particles in equilibrium, depending on pH & pKa.

Answer 11

Henderson Hasselbach Equation

Question 12

Increases renal clearance of drugs

Answer 12

Ionization

Question 13

Is usually down a concentration gradient

Answer 13

Drug permeation

Question 14

The greater the concentration gradient, the _______ the drug permeation.

Answer 14

Faster

Question 15

Is the density of blood supply & speed of blood flow. There

relationship is directly proportional.

Answer 15

Tissue vascularity

Question 16

Is the available area for permeation.

Answer 16

Surface area

Question 17

The greater the surface area, the _______ the diffusion.

Answer 17

Faster

Question 18

Length of the diffusion path

Answer 18

Thickness

Question 19

Mechanism of Drug Passage Across Membranes

Answer 19

Passive, Facilitated, Active & Pinocytosis

Question 20

Charged particles. Water soluble molecules are excluded from crossing many barrier.

Answer 20

Aqueous solubility

Question 21

Within large compartments. Involves crossing of molecules across a tight junction. From area of higher to lower concentration. Plasma protein bound drugs cannot permeate thru aqueous process.

Answer 21

Aqueous diffusion

Question 22

Entry into cells by very large substances (uses energy)

Answer 22

Endocytosis

Question 23

For an orally administered drug, Absorption depends on

Answer 23

Disintegration, Dissolution & Diffusion