M2 Flashcards
What is Loperamide?
anti-diarrheal and an opiate
methadone
tx opiate addiction; longer duration of action; withdrawal is less severe
most combo opiate drugs have acetaminophen
can be hard on liver; do don’t double dose - for short term pain
most commonly used
morphine
most potent drug
Fentanyl
which has no miotic effect?
meperidine
good choice drug! which has an added NE SE reuptake inhibitor effect/ should be cautioned with pt’s taking MAO, SSRI, tri…?
MOA: Bind to opioid receptor and weakly inhibits NE + 5HT
Tramadol (chronic pain tx)
pupil overdose response
pupil withdrawal response
constricted
dilated
Which drug should you NOT proscribe if not trained addiction management?
Buprenorphine (mixed agonist/antagonist)- shorter acting, less risk of lethal overdose, used in opiate addiction
triad of opiate overdose?
pinpoint pupils, respiratory depression, coma
what is most commonly used to treat overdose?
naloxone- injection only (nasal version)
what is most commonly used to treat opiate dependence? (not used for withdrawal- need to be clean at least 7-10 days before starting)
naltrexone (oral)
other warning signs of drug overdose:
purple blue fingernails/skin, clammy pale, difficulty speaking, nausea
