M1

Question 1

ACE Inhibitors:

Answer 1

Benazepril (Lotensin)
Captopril
Enalapril
Fosinopril
Lisinopril
Moexipril
Perindopril
Quinapril (Accupril)
Ramipril
Trandolapril

*PRIL (10)

Question 2

Angiotension-Receptor Blockers (ARBs):

Answer 2

Azilsartan
Candesartan
Eprosartan
Irbesartan
Losartan
Olmesartan
Telmisartan
Valsartan

*ARTAN (8)

Question 3

Renin Inhibitor:

Answer 3

Aliskiren

Question 4

Beta Blockers:

Answer 4

Atenolol*
Bisoprolol*
Carvedilol
Labetalol
Metoprolol*
Nadolol
Nebivolol*
Propranolol
* = beta 1 selective

Question 5

Beta 1 Selective Blockers:

Answer 5

Atenolol*
Bisoprolol*
Metoprolol*
Nebivolol*

MAN-B

Question 6

Thiazide Diuretics:

Answer 6

Chlorthalidone
Hydrochlorothiazide (HCTZ)
Metolazone

Question 7

Loop Diuretics:

Answer 7

Bumetanide
Furosemide (Lasix)
Torsemide

Question 8

“Potassium-Sparing” Diuretics:

Answer 8

Amiloride
Eplerenone (Inspra)
Spironolactone (Aldactone)
Triamterene

Question 9

Carbonic Anhydrase Inhibitors:

Answer 9

Acetazolamide (Diamox)

Methazolamide

Question 10

Osmotic Diuretics:

Answer 10

Mannitol (Osmitroll)

Question 11

Vasodilators- Calcium Channel Blockers:

Answer 11

Amlodipine (Norvasc)
Diltiazem
Felodipine
Isradipine
Nifedipine (Procardia)
Verapamil

Hydralazine
Minoxidil

Question 12

Parenteral Agents:

Answer 12

Fenoldopam
Nitroprusside (Nitropress)

Question 13

Centrally Acting Alpha-2 Agonists:

Answer 13

Clonidine

Methyldopa

Question 14

Alpha Blockers:

Answer 14

Doxazosin (Cardura)
Prazosin (Minipress)
Terazosin (Hytrin)

Question 15

What is the MOA for ACE inhibitors?

Answer 15

prevent conversion of angiotension I to angiotension II

Question 16

MOA for:
Benazepril (Lotensin)
Captopril
Enalapril
Fosinopril
Lisinopril
Moexipril
Perindopril
Quinapril (Accupril)
Ramipril
Trandolapril

Answer 16

prevent conversion of angiotension I to angiotension II

Question 17

what is the ACTION of ACE inhibitors?

Answer 17

Reduce peripheral vascular resistance

Reduce the inactivation of bradykinin

Results in vasodilation (arteries and veins) as well as decreased sodium and water retention

Question 18

What are ACE inhibitors used for?

Answer 18

Alone or in combination for HTN

Also slow progression of diabetic nephropathy

Good for patients with diabetes

Used in the care of patients following a heart attack

Considered first-line therapy

Question 19

What are the adverse effects of ACE inhibitors (7)?

Answer 19

Dry cough

Thought to be due to increased levels of bradykinin in the lungs

Increased blood potassium concentration “Hyperkalemia”

Skin rash

Hypotension

Fever

Fetotoxic – cause problems with fetal circulation

Question 20

ACE inhibitors should NOT use in combination with potassium-sparing diuretics- True or False?

Answer 20

TRUE

Question 21

What is the MOA for Angiotension II Receptor Blockers (ARBs)?

Answer 21

antagonist at AT1 receptor (alternatives to ACE inhibitors)

Question 22

What is different about the effects of ARBs compared to ACE inhibitors in terms of effect?

Answer 22

ARBs do NOT increase bradykinin levels

Question 23

What is different about the side effects of ARBs compared to ACE inhibitors?

Answer 23

**Risk of cough significantly decreased

Fetotoxic- Not to be used in pregnancy

Question 24

MOA of Renin inhibitor?

Answer 24

directly inhibits renin

**Acts earlier than ACE inhibitors or ARBs

Question 25

How are Renin inhibitors metabolized?

Answer 25

Metabolized by p450 system
**Subject to drug interactions
(NSAIDs reduce effectivity)

Question 26

Adverse Effects of Renin inhibitors?

Answer 26

Cough (less often than ACE inhibitors)

Hyperkalemia is common

Contraindicated in pregnancy