Lymphomas - Non-Hodgkin's Lymphoma Flashcards
How are Non-Hodgkin’s Lymphomas broadly classified in terms of origin?
What proportion of NHL are B-cell origin?
80%
What percentage of NHL are T-Cell origin?
20%
What is the commonest B-cell lymphoma?
Diffuse large B-cell lymphoma
What are causes of NHL
- Immunodeficiency - Drugs, HIV
- Toxins
- Congenital
- H. pylori
What is Burkitt’s lymphoma assocaited with?
EBV
How are NHL classified based on grade?
High and low grade
In terms of how aggressive a malginancy is, how aggressive is a neoplasm of non-dividing mature lymphocytes?
Indolent
What is the second commonest NHL?
Follicular lymphoma
In terms of how aggressive a malginancy is, how aggressive is a neoplasm of proliferating lymphoblasts?
Aggressive
How does Follicular lymphoma tend to present?
- Painless lymphadenopathy - more than one site
- Some have B-symptoms
What are adverse prognostic factors in NHL?
- Age >60 years
- Stage III or IV, i.e. advanced disease
- High serum LDH
- Performance status (ECOG 2 or more)
- More than one extranodal site involved
What is follicular lymphoma classed as in terms of grading?
Low-grade
What are features of diffuse B-cell lymphoma?
- Painless lymphadenopathy - one or several sites.
- Bowel symptoms - due to compression or infiltration of the gastrointestinal tract.
- May be ‘B symptoms’
Are B-symptoms more or less common in NHL than Hodgkins lymphoma?
Less common - if present indicates disseminated disease
What is the most rapidly proliferating lymphoma?
Burkitts lymphoma
How does burkitts lymphoma commonly present?
- Rapidly growing jaw tumour
- Abdominal mass - associated with bone marrow involvement.
- Other common sites are the central nervous system, the kidney and the testis.
Who does Burkitt’s lymphoma commonly present in?
Children - males more commonly
How aggressive is Burkitt lymphoma?
Highly aggressive
What is the more common presentation of Burkitt’s lymphoma that is associated with EBV (in africa)?
Jaw lymphadenopathy
What type of lymphoma is assocaited with EBV?
Burkitt’s lymphoma
How do Burkitt’s lymphomas present when not associated with EBV?
Extranodal involvement of the abdomen
