Lymphoma Flashcards
Nodular lymphocyte predominant HL pathologic appearance and immunophenotyp[
popcorn appearance, CD15-, CD30-. CD45+
Classical HL immunophenotype
CD15+, CD30+
Stage I/II vs stage III/IV HL
one side or both side of diaphragm
Brentuximab vedotin AEs
peripheral neuropathy and potentiating bleomycin pulmonary toxicity
Treatment after 1st relapse cHL
ICE followed by autoSCT
Treatment of cHL relapsed after auto-SCT
brentuximab vedotin then alloSCT
HCV related lymphoma
splenic marginal zone lymphoma
Mantle cell lymphoma cytogenetics
t(11;14)
Follicular lymphoma cytogenetics
t(14;18)
Marginal zone lymphoma cytogenetics
t(11;18)
Lymphoplasmacytic lymphoma
t(9;14)
Treatment of aggressive FL
R-CHOP
Treatment of stage I or II gastric MALT lymphoma
Treat H pylori if present, otherwise radiation or R
Treatment of splenic marginal zone lympoma
Treat HCV if present, otherwise splenectomy or R
Infection associated with cutaneous MALT lymphoma
Borrelia Burgdorferi
Burkitt lymphoma cytogenetics
t(8;14)
Two types of DLBCL and survival
germinal center B-cell - better survival
activated B-cell - worse survival
First line treatment of primary mediastinal B cell lymphoma
DA-R-EPOCH
Primary mediastinal B cell lymphoma cytogenetics
t(16;X)
Morphologic description for Burkitt lymphoma
starry sky
Treatment of Burkitt lymphoma
CODOX-M or R-HyperCVAD
Associated disease with enteropathy-associated T-cell lymphoma
Celiac
Associated diseae with extranodel NK/T-cell lymphoma
EBV, often in Asia
Anaplastic large cell lymphoma mutation and cytogenetics
ALK subtype: t(2;5)
Hallmark cells disease
Anaplastic large cell lymphoma
Cell of origin for angioimmunoblastic T cell lymphoma
Follicular helper T-cell
Impact of ALK mutation on anaplastic large cell lymphoma
ALK mutated has better OS
Symptoms of angioimmunoblastic T cell lymphoma
Effusions, arthritis, hemolytic anemia
Lymphoma associated with breast implants
Anaplastic large cell lymphoma, ALK negative
High risk MM cytogenetics
t(14;16), t(14;20), del 17p
Treatment of Mantle cell lymphoma
R-CHOP
Anaplastic large cell lymphoma treatment
CD30+: BV with CHP
CD30-: CHOEP
Diagnosis of onion skinning germinal centers
Unicentric Castleman