GI Flashcards

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1
Q

Treatment of locally advanced esophageal cancer

A

Neoadjuvant chemoradiation with carbo and paclitaxel (no traztuzumab)

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2
Q

Second line therapy for metastatic esophageal cancer

A

Ramucirumab

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3
Q

First line therapy for metastatic esophageal cancer

A

FOLFOX+/- Traztuzumab

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4
Q

Risk factors for adenocarcinoma of esophagus (3)

A

Obesity, Barret’s, GERD

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5
Q

Risk factors for squamous cell carcinoma of esophagus

A

Smoking, alcohol, ionizing radiation

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6
Q

Treatment of local esophageal cancer in poor surgical candidate

A

Endoscopic mucosal resection

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7
Q

Gene for hereditary diffuse gastric cancer

A

CDH1

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8
Q

Management of hereditary diffuse gastric cancer

A

prophylatic gastrectomy

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9
Q

Management of resectable gastric cancer (2)

A

Neoadjuvant ECF

Adjuvant 5FU + radiation

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10
Q

Treatment of HER2 mutated metastatic gastric cancer

A

trastuzumab + cisplatin/5FU

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11
Q

Treatment of HER2- metastatic gastric cancer

A

ECF or FOLFOX

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12
Q

Second line treatment of metastatic gastric cancer

A

ramcirumab+paclitaxel

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13
Q

HNPCC genes (3)

A

MSH2
MSH6
PMS2

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14
Q

FAP gene

A

APC

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15
Q

Cowden syndrome gene

A

PTEN

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16
Q

Gene with resistance to anti-EGFR therapy

A

NRAS or KRAS

17
Q

Surgical approach for rectal tumor in distal one third of recturm

A

Abdominoperineal resection (APR)

18
Q

Surgical approach for proximal two thirds of the rectum

A

Low anterior resection (LAR)

19
Q

Adjuvant CRC treatment

A

FOLFOX

20
Q

Treatment of resectable rectal cancer

A

chemoradiation -> surgery -> adjuvant chemo

21
Q

Treatment of metastatic RAS WT CRC left sided

A

FOLFOXIRI (or FOLFOX) + cetuximab/panitumumab

22
Q

Treatment of metastatic RAS mt CRC right sided

A

FOLFOXIRI (or FOLFOX) = bevacizumab

23
Q

Adjuvant pancreatic cancer Tx in fit patients

A

FOLFIRINOX

24
Q

Adjuvant pancreatic cancer in unfit patients

A

Gem/Cis

25
Q

EpCAM mutation disorder

A

Indirectly causes Lynch

26
Q

Mutation associated with 5FU toxicity

A

DPYD

27
Q

Other tumors associated with FAP (2)

A

Desmoid tumors

Duodenal adenoma

28
Q

TACE vs RFA for HCC

A

TACE for larger tumors (>4cm), RFA for smaller

29
Q

Initial treatment for SCC anal cancer

A

CRT with 5-FU and mitomycin c

30
Q

When to assess response after first line CRT in anal cancer

A

26 weeks

31
Q

Treatment locoregional failure in rectal cancer

A

Surgery (APR)

32
Q

First line treatment for metastatic rectal cancer

A

Cisplastin + 5FU

33
Q

Adjuvant therapy for pancreatic cancer

A

Gem+capcitabine or FOLFIRINOX

34
Q

Neoadjuvant therapy for pancreatic cancer

A

FOLFIRINOX

35
Q

Chemotherapy for metastatic biliary cancer

A

Gem+cis

36
Q

Imaging findings for HCC (arterial, venous, and delayed phase findings)

A

Arterial: increased
Venous: decreased
Delayed: persistent washout