Head/Neck and Endocrine

Question 1

Fossa of Rosemillar cancer type and virus

Answer 1

nonkeartinizing and undifferentiated cancer, EBV

Question 2

Field cancerization implications

Answer 2

H/N cancer may have second cancer in aerodigstrive tract

Question 3

Most important prognostic factor for H/N SCC

Answer 3

Stage at time of diagnosis

Question 4

Treatment of early stage H/N SCC

Answer 4

surgery or radiation (depending on performance status)

Question 5

Role for accelerated fraction radiation

Answer 5

Only without chemotherapy

Question 6

Role for concomitant chemoradiation as front line

Answer 6

Locally advancement (stage III or IVA/B)

Question 7

Chemo given with radiation for H/N SCC

Answer 7

Cisplatin or carboplatin

Question 8

Combination chemotherapy for metastatic or unresectable H/N SCC surgery unable to tolerate radiation

Answer 8

Cisplatin+5-FU+cetuximab

Question 9

Second line therapy for metastatic H/N SCC

Answer 9

Nivo/Pembro or cetuxiumabn

Question 10

Treatment of salivary tumor

Answer 10

Resection

Question 11

Orophayngeal cancer first line treatment

Answer 11

Chemoradiation with involvement of bilateral neck

Question 12

Treatment of persistent disease after completion of chemoreadiation

Answer 12

Surgery

Chemo (if not surgical candidate)

Question 13

Familial syndromes for MTC

Answer 13

MEN2A and MEN2B

Question 14

Mutations in differentiated thyroid cancer

Answer 14

BRAF V600E

Question 15

Indication for FNA in thyroid mass

Answer 15

Normal/high TSH or non-hyperfunctional nodule on radionucleotide scan

Question 16

Management of negative FNA

Answer 16

Rebiopsy in 3+ months

Question 17

Markers for MTC (2)

Answer 17

Calcitonin and CEA

Question 18

Total thyroidectomy indications (3)

Answer 18

> 4cm differentiated
MTC
Anaplastic (may need neoadjuvant therapy)

Question 19

Indications for RAI postthyroidectomy

Answer 19

Differentiated with extrathyroid extension

Question 20

TSH suppression role

Answer 20

Differentiated only, stage II+

Question 21

Monitoring after RAI

Answer 21

Tg, anti-Tg Ab

Question 22

Treatment of metastatic differentiated thyroid

Answer 22

Sorafanib or lenvatininib

Question 23

Treatment of metastatic MTC

Answer 23

Vandetanib or cabozantinib

Question 24

Treatment of anaplastic thyroid cancer

Answer 24

EBRT with doxorubicin radiosensitizing

Question 25

Systemic therapy for adrenocortical carcinoma

Answer 25

Platinum + etoposide + doxorubicin +mitotane

Question 26

Radiographic findings of adrenocortical carcinoma

Answer 26

> 10 Hounsfield units

Delayed washout, irregular borders

Question 27

Mutation associated with adrenocortical carcinoma

Answer 27

TP53

Question 28

Cell of origin for pheochromocytoma

Answer 28

chromaffin cell of adrenal medulla

Question 29

Genetic associations with pheochromocytoma (3)

Answer 29

MEN2A/2B
NF1
VHL

Question 30

Biochemical testing for pheochromocytoma

Answer 30

Fractionated plasma free metanephrines

24 hour urine fractionated metanephrines

Question 31

Preoperative care before pheo resection

Answer 31

alpha1 blockade (phenoxybenzamine)

Question 32

Scan for pheochromocytoma

Answer 32

131I-MIBG scan

Question 33

Metastatic pheochromocytoma chemo

Answer 33

cyclophosphamide, vincristine, dacarbazine

Question 34

Lymphoepithelial carcinoma virus

Answer 34

EBV