Lymphoma

Question 1

What is the Ann Arbor classification system?

Answer 1

1 = 1 node group involves
2 = >1 node group involved, same side of diaphragm
3 = >1 node group involved, both sides of diaphragm, including spleen 
4 = extranodal involvement e.g. liver. 

Add A if no B symptoms, add B if there are B symptoms e.g. weight loss, night sweats. Prognostic.

Question 2

What is a Reed Sternberg cell?

Answer 2

Seen in Hodgkins. Large binucleate B cell with more cytoplasm.

Question 3

What chemo is used in H Lymphoma?

Answer 3

A = adriamycin
B = bleomycin
V = vinblastine
D = dacarbazine

Question 4

What is the CRAB criteria for plasma cell myeloma diagnosis?

Answer 4

C = calcium elevation
R = renal insufficiency
A = anaemia
B = bone disease

Also can be biomarkers of malignancy e.g. cloncal plasma cell >60%, SFLC ratio >100, focal lesions on MRI

Question 5

What is the difference between plasma cell myeloma and MGUS?

Answer 5

MGUS: no BJ protein, no lytic bone lesions, marrow plasma cells <10%, no CRAB.

Question 6

What is R CHOP chemo?

Answer 6

R = rituximab
C = cyclophosphamide
H = doxorubicin
O = vincristine 
P = prednisolone 

Used in non H lymphoma

Question 7

What is plasmocytoma?

Answer 7

Single localised tumours consisting of monoclonal plasma cells (e.g. tissue instead of bone marrow). May have M protein, but no other features of plasma cell myeloma.