Lymphoma

Question 1

CD markers on B cells

Answer 1

CD19, 20

B = big

Question 2

CD markers on T cells

Answer 2

CD2, 3, 5, 7

T = tiny

Question 3

CD markers on plasma cells

Answer 3

CD38, 138

Question 4

CD markers on NK cells

Answer 4

CD2, 16, 56

Question 5

CD markers on myeloid cells

Answer 5

CD13, 33 (3 = sideways M)

Question 6

Mantle cell lymphoma
Oncogene
Protein
Translocation
Effect

Answer 6

Oncogene - BCL1
Protein - Cyclin D1
Translocation - t(11;14)
Effect - increased proliferation

Question 7

Follicular NHL
Oncogene
Protein
Translocation
Effect

Answer 7

Oncogene - BCL2
Protein - Bcl2
Translocation - t(14;18)
Effect - Decreased apoptosis

Question 8

Burkitt lymphoma
Oncogene
Protein
Translocation
Effect

Answer 8

Oncogene - C myc
Protein - Myc
Translocation - t(8;14)
Effect - increased proliferation

Question 9

DLBCL
Oncogene
Protein
Translocation
Effect

Answer 9

Oncogene - BCL6
Protein - Bcl6
Translocation - t(3;14)
Effect - Deregulated transcription

Question 10

CD markers on Reed Sternburg cells

Answer 10

CD30

Lack normal B cell markers 19 and 20

Question 11

CD markers on CLL

Answer 11

CD19 / 23 (normal B cell markers)

CD5 (normally a T cell marker)

Question 12

What marker aids in prognosis for aggressive NHL?

Answer 12

LDH

Question 13

What marker aids in prognosis for indolent NHL?

Answer 13

Beta-2 microglobulin

Question 14

Richter’s Transformation

Answer 14

Rare transformation of indolent lymphoma (especially follicular center cell lymphoma) to much more aggressive large cell lymphoma. Rarely curable.