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Hematology > Bleeding Disorders > Flashcards

Bleeding Disorders Flashcards

1
Q

Treatment for ITP (5)

A

Corticosteroids, IVIG, splenectomy (source of platelet destruction), rituximab, thrombopoiesis stimulating drugs (romiplostim and eltrombopag)

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2
Q

Romiplostim
Use
Mechanism
Side effect

A

Used for ITP
“Peptibody”. Ig heavy chain fused to peptide analog of thrombopoietin
May cause marrow fibrosis

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3
Q

Eltrombopag
Use
Mechanism
Side effect

A

Used for ITP
TPO receptor agonist
May cause marrow fibrosis

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4
Q

Drugs that cause thrombocytopenia (5)

A

Penicilliin, quinine, quinidine, sulfa drugs, rifampin

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5
Q 
Lupus anticoagulant
aPTT
INR
Mixing study
What neutralizes?
A

Prolongs aPTT
Sometimes lengthens INR
Does NOT correct w/ mixing
Neutralized by excess lipid or platelets

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6
Q

Lab effects of heparin

A

Long aPTT
Long thrombin time
Only long PT / INR at high levels
Does NOT correct w/ mixing (inhibitor)

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Hematology (8 decks)

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