Anemia Flashcards
1
Q
Inflammation Serum iron TIBC Ferritin Hepcidin
A
Low serum iron
Low TIBC
High ferritin
High hepcidin
2
Q
Things that decrease hepcidin (4)
A
Low iron, HFE mutation, ineffective erythropoiesis, liver disease
3
Q
Things that increase hepcidin (2)
A
High iron and inflammation
4
Q
5 signs in chronic iron deficiency
A
Atrophic glossitis Pica Spoon nails Cheilosis - fissures at angles of mouth Delayed sensory development, motor function, language skills in kids.
5
Q
Which organ is most susceptible to iron overload?
A
Liver
6
Q
Sideroblastic anemia
A
Iron is retained in mitochondria around red cell nucleus. Mitochondria can’t generate heme ring well.
7
Q
What is the most common cause of anemia in hospitalized pxs?
A
Inflammation
8
Q
Causes of anemia of inflammation (3)
A
Infection, autoimmune, CANCER
9
Q
2 mechanisms of anemia of inflammation
A
- Inflammation → IL-6 and JAK/STAT → increased hepcidin → impaired release of stored iron
- Low epo production.
