Lymphoma Flashcards

1
Q

What is lymphoma?

A

cancer of immune system
primarily affects lymphatic system (they are the highway of the body)

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2
Q

what is lymphoma classified by?

A
  1. degree of cell differentiation
  2. origin of predominantly malignant cells
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3
Q

what broad categories of lymphoma are important?

A
  1. Hodgkin Lymphoma
  2. Non- Hodgkin lymphoma (WORSER)
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4
Q

Lymphoma can originate in?

A

Lymph nodes
spleen
thymus gland
tonsils
adenoids
bone marrow
digestive tract

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5
Q

How do you stage lymphomas?

A

Based on the diaphragm

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6
Q

STAGE ONE:

A

Earliest stage, cancer only involves single lymph node group

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7
Q

Stage 2:

A

several lymph nodes either above or below the diaphragm

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8
Q

stage 3:

A

several lymph nodes both above and below the diaphragm

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9
Q

stage 4:

A

widespread beyond lymph nodes and slpeen; spread to one or more organs
(THE WORST CASE SCENARIO)

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10
Q

Hodgkin Lymphoma characterstics:

A

develops from abnormal b cells
RARE
5 subtypes
HIGH CURE RATE VERY TREATABLE

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11
Q

s/s of hodgkins:

A

firm painless enlargement of 1 + lymph nodes fatigue weakness NIGHT SWEATS weight loss enlarged painless lymph nodes

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12
Q

what are the two common age groups for hodgkins?

A

16-34
and 55 and older

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13
Q

risk factors of hodgkins?

A

EBV: MONO
HIV
weakened immune system
family history

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14
Q

Non-Hodgkin characteristics?

A

develop from abnormal b or t cells
has 60 subtypes
cure rate varies
MORE prevelant in 50 -70 age group
WAY HARDER TO TREAT

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15
Q

risk factors for non hodgkins?

A

viral infections
autoimmune
infection with h pylori
exposure to chemicals

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16
Q

s/s of non hodkins:

A

same as hodgkins
EXCEPT NO REED-STERNBURG
may have CNS involvement (neuropathy , headache)

17
Q

what types of non hodgkins are there?

A

low grade or indolent: slow growing lifelong disease
intermediate grade: moderately aggressive
high grade: aggressive and poor prognosis

18
Q

Diagnostic testing for HL and NHL

A

cbc
cxr
ct scan
lymph node biopsy to identify type of cell and pattern (b vs t cells)
shows reed sternberg cells in HL only
bone marrow biopsy

19
Q

NHL treatment:

A

based on type and stage, prior treatment, ability to tolerate therapy
Options:
watchful waiting ( only in NHL low grade stage)
chemotherapy
radiation
combo of radiation/ chemo in later stages
stem cell transplant

20
Q

how can we manage lymphoma?

A

Fatigue: balance acvitity w rest
Nutrition: monitor weight, fluids and food intake
Risk for infection: myelo suppression
body image: weight loss alopecia sterility
hopelessness: support groups ACS family planning options

21
Q

Treatments for lymphoma?

A

surgery
chemo
photodinaic therapy: use of drugs that come active when exposed to light
biological therapy: monocolal antibodies, growth factors, vaccines
radiation