Lymphoma Flashcards
1
Q
What is Lymphoma?
A
A group of cancers that affect the lymphocytes inside the lymphatic system.
These cancerous cells proliferate within the lymph nodes and cause abnormally large lymph nodes (lymphadenopathy)
2
Q
What are the two categories of lymphoma?
A
- Hodgkin Lymphoma and Non- Hodgkin Lymphoma
3
Q
What is the common age for Lymphoma?
A
- Bimodal age distribution (peaks at 20 and 75 years old)
4
Q
How common is Hodgkin’s Lymphoma?
A
1 in 5 cancers are lymphomas
5
Q
What are the Risk Factors for Hodgkin’s Lymphoma?
A
- HIV
- EBV
- Autoimmune conditions: RA and sarcoidosis
- Family History
6
Q
How does Lymphoma present?
A
- Lymphadenopathy is the key presenting symptom
- They are characteristically non-tender and feel rubbery
- Pain can some times be felt when they drink alcohol
7
Q
Where is lymphadenopathy commonly seen?
A
- Neck, Axilla, Inguinal
8
Q
What are some of the B symptoms?
A
- Fever
- Weight Loss
- Night Sweats
9
Q
What are some of the other symptoms of Lymphoma?
A
- Fatigue
- Itching
- Cough
- SOB
- Abdo pain
- Recurrent infections
10
Q
How is Hodgkin’s Lymphoma characterised?
A
- Hodgkin/ Reed- Sternberg cells
- These are large, multinucleated malignant cells
- Described as having an owl like appearance
11
Q
What are the types of Hodgkin Lymphoma?
A
- Classical
- Nodular Lymphocyte- predominant
12
Q
What are the types of Classical Hodgkin Lymphoma?
A
- Nodular sclerosis
- Mixed cellularity
- Lymphocyte rich
- Lymphocyte depleted
13
Q
What is Nodular Lymphocyte- predominant Hodgkin Lymphoma?
A
- Significant make preponderance
- common in black ethnicity
- lymphohistiocytic Reed- Sternberg variant
