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Exam 3 Histology > Lymphoid system > Flashcards

Lymphoid system Flashcards

1
Q

lymphoid organ types

A

primary or secondary

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2
Q

primary lymphoid organs

A

Bone Marrow or Thymus

discrete, covered by epithelium/CT

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3
Q

secondary lymphoid organs

A

isolated masses of cells

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4
Q

Immunocompetent T cells develop in the

A

thymus

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5
Q

immunocompetent B cells develop in the

A

bone marrow

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6
Q

immunonocompetent cell development in primary organ

A

thymocyte/ B cell precursor> developing cells with receptors against anything > anything BUT SELF

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7
Q

Thymus

A

involutes with age. Lobulated with septa. “Starry night”, white spaces are macrophages. Surrounded by CT capsule, which septa penetrate inwards from. Basophillic areas are full of lymphocytes while lighter region is medulla (continuous)

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8
Q

epithelioreceptor cells

A

long extending fibers that connect via desmosomes. The form network supporting lymphocytes, and release hormones that recruit lymphocytes to mature. (Thymus has no Reticular fibers)

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9
Q

Hassalls corpuscles

A

whorls of epithelioreceptor cells, reside in thymic medulla, diagnostic for thymus. Grow with age, even post puberty.

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10
Q

Secondary lymphocytes are classified as either?

A

unencapsulated or encapsulated

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11
Q

Unencapsulated secondary lymphoid organs

A

tonsils, peyers patch, appendix

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12
Q

encapsulated secondary lymphoid organs

A

Lymph nodes and spleen

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13
Q

Secondary lymphoid all have what?

A

nodular and diffuse lymphoid tissue

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14
Q

Lymphoid nodules

A

B cell proliferation. Have germinal center. Also contain macrophages. When a B cell is activated, it will move from nodule to CT, where it becomes plasma cell.

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15
Q

diffuse zones

A

are between nodules, full of T cells

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16
Q

MALT

A

mucose associated lymphoid tissue

occurs in lamina or submucosa

17
Q

Tonsil types

A

palatine, pharyngeal, lingual: all look the same at high magnification - need to see surface covering to distinguish

18
Q

palatine tonsil

A

stratified squamous epithelium of oral cavity (SSNKE). Crypts present increase surface area.

19
Q

Pharyngeal tonsil

A

respiratory epithelium covering.

20
Q

Peyers patch

A

usually in ileum, mucosa related. M cells present in epithelia, which give broken appearance

21
Q

M cells

A

microfold cells, deep basal invaginations. take in antigens via pinocytosis

22
Q

appendix

A

unencapsulated secondary lymphoid. Lumen lined by epithelium, nodules and lamina.

functions: immune surveillance, endocrine organ, reserve of gut flora, surgical substitute

23
Q

lymph node

A

variable sizes, concentrated on neck, axilla, and groin. filter lymph and expose antigens to immune cells

surrounded by dense CT. Medullary cords and sinuses.

24
Q

medullary cord

A

loose CT, highly cellular. Reticular fibers. Lots of plasma cells.

25
Q

medullary sinuses

A

venous channels that divide cords, discontinuous endothelium. traversed by reticular fibers

26
Q

Splenic cord/sinuses

A

similar to lymph medullary except: blood cells in both; no reticular fibers in sinuses

27
Q

Lymph flow

A

afferent> efferent, with efferent often becoming afferent of next node. More afferent than efferent slows down fluid- more time for antigen exposure.

28
Q

3 mechanisms to insure lymphocytes meet pathogens

A

1) sinuses lined by discontinuous endothelium
2) reticular fibers transverse all sinuses
3) afferent lymphatics outnumber efferent> bottleneck

29
Q

High Endothelial Values

A

lymphocyte entry, lymphocytes stick.

30
Q

Spleen functions

A

immune response (b/t), destroy damaged RBC, sequester monocytes, heatopoisis, storage of platelets, recycling iron

31
Q

Does the spleen have cortex/ medulla?

A

NOPE. Just random pulp

32
Q

Red pulp

A

full of RBC, eosinophilic in H/M

33
Q

white pulp

A

full of WBC, basophilic on H/M

34
Q

Traveculae in spleen

A

extend into spleen, artery and vein

35
Q

red pulp cords

A

loose CT/ reticular fibers. Contains RBC, platelets, macrophages, plasma cells, lymphocytes

36
Q

Red pulp sinuses

A

venous channels with discontinuous endothelial cells.

discontinuous basal lamina. NO RETICULAR FIBERS

37
Q

PALS

A

pulp areas surrounding central artery

38
Q

marginal zone

A

location of first antigen exposure- lots of reticular fibers

39
Q

spleen has open circulation

A

filters out old RBCvia stave cells in cord areas.

Exam 3 Histology (4 decks)

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