Lymphocyte maturation Flashcards
Where does the development of mature B-cells occur in dogs?
Ileal Peyer’s patch
Where does the development of mature B-cells occur in birds
Bursa of Fabricius
Bone marrow
Where does the development of mature B-cells occur in humans, primates and rodents
Bone marrow
Where does the development of mature B-cells occur in rabbits
Appendix
In what species does the B-cells mature in the Ileal Peyer’s patch
Ruminants (cows, sheep)
Dogs
Pigs
Horses
Where do T-cells develop
Thymus
Describe the function of the thymus
- Site of the education of T-cells which occurs during foetal life and first few months of life, regresses with age
Describe the function of the red pulp of the spleen
Filters blood for foreign pathogens
Describe the function of the white pulp of the spleen
Are where T and B cells are found
Describe the function of lymph nodes
Presentation of antigen to lymphocytes and mount an immune response if necessary
What does MHC class 1 display on healthy cells
host cell peptide “self” is in the MHC groove
What does MHC class 2 display on infected cells
MHC groove is filled by a peptide derived from the pathogens proteins “non-self”
What does the MHC do
controls how the immune system detects and responds to specific antigens.
Display peptide fragments for recognition by appropriate T-cells
How are T cells educated
- Use +ve selection to retain T cells which recognise the bodies own MHC
- Use -ve selection to eliminate T-cells which respond to “self peptides” in the MHC
What are the outcomes of thymic education
- central tolerance (T-cells which do not react to their body’s own peptide antigens)
- Huge T cell diversity in peptide recognition (recognise any non-self peptide on an APC)
- Maturation of T cells (T helper cells, cytotoxic T cells)
