Bone marrow and Leukocytes Flashcards
What are the cellular components of blood
- Erythrocytes
- Platelets (thrombocytes)
- Leucocytes
What are the 2 types of Leucocytes
- Granular Leucocytes
- Non-granular Leucocytes
List 3 examples of Granular leucocytes
- Neutrophils
- Eosinophils
- Basophils
List 2 examples of non-granular leucocytes
- Monocytes
- Lymphocytes
Describe the typical features of neutrophils
- 2 or more lobed nucleus
- often connected by thin strands of chromatin
- sparse granules
What is the most common leucocyte to see in the blood
Neutrophils
what do neutrophils do
- They are chemotaxic
- Under go phagocytosis (oxygen-dependent and oxygen-independent )
Where does oxygen-independent phagocytosis occur
- occurs in sites of poor blood flow or at abscesses
Where does oxygen-dependent phagocytosis occur
- killing after phagocytosis- often called respiratory burst
What are Heterophils
Do the same job as neutrophils but their granules stain red
Describe Neutrophil development in bone marrow
- Myeloblast
- Promyelocyte
- Myelocyte
- Metamyelocyte
- Band neutrophil
- Segmented neutrophil
What is left shift
occurs during infection and is where circulating neutrophil numbers increase and begin to see immature neutrophils (band forms) within the blood
Describe the features of Eosinophil
- 2 lobed nucleus
- Dense orange granules
- Blue cytoplasm
- strongly associated with allergy, parasites and fibrosis
- found less in healthy blood compared to neutrophils
Describe the features of basophil
- Lobed but not so well defined
- dense blue granules within cytoplasm
- rare in blood
- associated with parasitic infection and allergy
- extreme;y rare in the blood
What is the function of mast cells
involved in the response to allergy and parasitic infections
are found in tissues not blood
- can become cancerous
Describe the appearance of mast cells
- found in connective tissue
- Rounded nuclei
- granular cytoplasm
- granules release
What is special about monocytes and neutrophils
they arise from the same precursors
How do you tell between B and T cells
can’t tell between them on a blood smear
How do you count how many WBC are in a sample
- either use a machine
- or manually count
need to count when you use a machine
