Lymphatics Flashcards

0
Q

Postcapillary venule location

A

deep cortex of lymph node

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1
Q

Postcapillary venules

A

allow lymphocytes to leave blood stream and re-enter lymph node

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2
Q

postcapillary venule endothelium

A

“high” or tall endothelium

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3
Q

Blood supply of lymph node

A

enters/leaves at hilus. vessels use trabeculae for distribution & eventually enter parenchyma of node

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4
Q

Pig Lymph nodes

A

reversal of cortex & medulla

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5
Q

Birds & lymph nodes

A

birds do NOT have lymph nodes

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6
Q

Hemal Node location

A

widely distributed in ruminants & pigs

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7
Q

Hemal Node Microscopically

A
  • has nodules throughout, blood, and a capsule.

- does NOT have cortex/medulla, epithelium.

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8
Q

Tonsil types

A

Palantine, Pharyngeal, Lingual

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9
Q

Palantine & Lingual Tonsil characteristic feature

A

nonkeratinized stratified squamous epithelium

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10
Q

Pharengeal Tonsil Characteristic Feature

A

ciliated pseudostratified columnar epithelium

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11
Q

Tonsilar Crypts

A
  • invaginations of epithelium & LP into substance of tonsil

- not ALL tonsils have them

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12
Q

Tonsil Stromal Elements

A

Capsule (incomplete CCT at base w/o epithelium)

Septa (strands of CCT inwards from capsule, can connect to LP [has reticular ct. and CCT])

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13
Q

Reticular CT in tonils

A

throughout tonsil as part of stroma

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14
Q

Thymus locations

A

thoracic to cranial depending on species

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15
Q

Thymus microscopic appearance

A
  • lobules each with cortex & medulla continuous across them
  • thymic corpuscles
  • capsule
  • no lymph nodules
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16
Q

Thymic Corpuscles

A
  • made of degenerating Epithelial-Reticular Cells
  • only in medulla
  • may aid in t-cell differentiation
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17
Q

Epithelial-reticular cells job

A

help isolate t-cells from medulla and rest of body

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18
Q

Blood-Thymus Barrier

A
  • located only in cortex

- separates t-cells from blood to protect them from Ag while they’re maturing.

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19
Q

Components of Blood-Thymus Barrier

A
  1. Endothelial Cell
  2. Endothelial Cell Basal Lamina
  3. Some Ct & macrophages
  4. Epithelial-Reticular Cell Basal Lamina
  5. Epithelial-Reticular Cell Cytoplasm
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20
Q

Thymus Funtions

A
  1. Development & proliferation of T-cells
  2. Populates other organs with T-cells
  3. Humoral Factors made here
21
Q

Effects of Thymectomy

A

depends on animal’s age.

-young = compromised adaptive immunity

22
Q

Thymus does NOT

A

filter lymph or blood

23
Q

Spleen

A

largest lymphoid organ

24
Q

Spleen’s job

A

filters blood

25
Q

Spleen’s microscopic appearance

A
  • lymph nodules throughout, blood in red pulp, contains nodular arterioles.
  • NO cortex/medulla, or epithelium
26
Q

Spleen stroma

A

Capsule: thick with smooth muscle.
Trabeculae
Reticular CT throughout spleen

27
Q

White Pulp

A
  • splenic nodules
  • B-cells in secondary nodules
  • PALS
  • nodular arterioles
28
Q

PALS

A

Periarterial Sheaths of Lymphocytes

29
Q

PALS contain

A

T-cells

30
Q

PALS do this..

A

interconnect nodules (b-cells)

31
Q

Red Pulp

A

most of parenchyma of spleen

32
Q

Red Pulp contains.

A
splenic sinusoids (endothelium)
splenic cords
33
Q

splenic sinusoid

A

special type of capillary

can’t see them when there’s blood in the spleen

34
Q

splenic cord

A

between sinusoids & contains all elements of circulating blood

35
Q

Spleen’s blood supply

A

splenic a. -> trabecular aa. -> central aa. -> penicillar aa. ->splenic sinusoids -> pulp vv. -> trabecular vv. -> cranial mesenteric v. -> portal v.

36
Q

Spleen functions

A
  • early hematocytopoietic
  • blood filtration
  • blood storage (RBCs & platelets)
  • small role in immunity
37
Q

Cloacal Bursa

A

in birds only

38
Q

ID features of Cloacal Bursa

A

simple columnar or pseudostratified columnar epithelium

smooth mm. on outer wall

39
Q

Cloacal Bursa Microscopic features

A

simple columnar or pseudostratified columnar epithelium, LP of CCT, elongated lymph follicles, cortex/medulla per follicle, smooth mm. in outer wall

40
Q

Cloacal Bursa Function

A

B-cell proliferation & differentiation site in BIRDS

41
Q

Peyer’s Patches

A

aggregations of lymph nodules in lower S.I., cecum, ascending colon

42
Q

Deep Cortex/Paracortical Zone of Lymph Nodes

A

contains T-cells & postcapillary venules

where lymphocytes leave blood stream to re-enter lymph nodes

43
Q

Lymph node medulla’s characteristic arrangement

A

trabeculae-sinus-cord

44
Q

Medullary cords

A

irregular columns of lymphatic tissue separated by lymph sinuses

45
Q

Lymph node capsule

A

fibromuscular with CCT & small bit of smooth mm.

46
Q

General Functions of Lymphatic System

A
  • filtration of lymph/blood

- immunity

47
Q

What makes up sheathed arterioles in the spleen?

A

reticular cells & macrophages

48
Q

What tissue type predominates in sheep/ruminant spleens?

A

smooth m.

49
Q

In the thymus, what accounts for the difference in staining affinity between cortex & medulla?

A

the medulla has lower cell density & has more ER cells present.
the cortex has higher cell density

50
Q

What is the mammalian functional equivalent to the cloacal bursa?

A

bone marrow