Lymph nodes Flashcards
anus below dentate
superficial inguinal LN
glans penis, penile urethra and posterior calf
deep inguinal nodes
superior portion of the bladder
external iliac LN
inferior portion of the bladder
internal iliac LN
prostate
internal iliac LN
testes
para-aortic LN
upper third of rectum
inferior mesenteric LN
Also drains sigmoid colon
Metastatic prostate cancer spread to vertebra how?
Prostatic venous plexus –> vertebral venous plexus
Metastatic breast and lung cancer spread to thoracic spine how?
Azygos vein –> vertebral venous plexus
Where does isotype switching occur?
germinal center
Where does negative selection (deletion of T cell clones that strongly bind self-MHC ag) occur?
Fetal thymus
Where does VDJ recombination of immunoglobulin heavy chains occur?
Bone marrow (during B- cell maturation)
Where does affinity maturation occur?
germinal centers
Where do B-cell precursors proliferate and mature?
Bone marrow
Metastasis of SCC of cervix drain where first?
Internal iliac
B cells are located in what part of the LN?
Cortex
T cells are located in what part of the LN?
Paracortex (hypertrophy in mono)
T cells are located where in the spleen?
White pulp (PALS)
Lesions of medial foot
Superficial inguinal LN (medial track)
Lesions of lateral foot
Popliteal and inguinal LN (lateral track)
Scrotum, perineum, butt, skin of penis, ant abdominal wall (inf to umbilicus)
Superficial inguinal LN
upper 1/3 of esophagus
cervical nodes
middle 1/3 of esophagus
mediastinal or tracheobronchial nodes
eg scc
lower 1/3 of esophagus
celiac and gastric nodes (eg adenocarcinoma)
