Lymph Flashcards
T or F. Lymph vessels and fenestrated.
No.
Lymph vessels are a _____ layer of epithelial cells with an incomplete _______ lamina.
single
basal
Causes of lymphedema.
Blockade of vessel due to
filiarisis tropical parasite
cellulitis
breast (lymph node dissection)
Lymphangitis has bacterial growth so rapid that local and systemic tissue destruction includes
abscesses
cellulitis
septicemia
red streaks
What are some components of innate immunity?
NK
neutrophils
macrophages
complement
What can be described by specificity, diversity, memory, self/nonself recognition?
Adaptive immunity.
What is the order of Igs made in response to stimulus?
MADGE
What’s special about IgM?
isotope formed in primary response
IgA is a _______ antibody in tears, salive, gut, nasal.
secretory.
what does IgD activate?
B cells.
Immunoglobulin Dave activates Buster.
Which Ig is most common and is for opsonization for NK?
IgG
what does IgE do?
for degranulate mast and basophil
beeeeeeeeeeeeeeeeeeeeeeeeeeees
what are the primary lymphoid organs?
Thymus, bone marrow
What are the secondary lymphoid organs?
Lymph nodes, spleen, malt
Which are the encapsulated lymph organs?
thymus, spleen, lymph nodes.
Thymocytes enter the _____ via the ______.
cortex
corticomedullary junction of trabeculae.
Cortex contains what types of cells?
macrophages, apcs, epithelial reticular cells.
What is positive and negative selection of thymocytes in thymus?
positively select for those that can recognize mhc 1 and 2
negatively select for self recognition
immunocompetent naive T cells migrate out of the medulla via
venues and efferent lymphatic vessels
The medulla is characterized by
hassalls corpuscles
Maturation of thymocytes in cortex stimulated by hormones of
epithelial reticular cells
T or F. Thymoctytes leave the cortex as naive, immunocompetent mature T cells.
True.
What isolates thymocytes from exposure to antigens/blood borne macromolecules?
blood thymus barrier
What does a Treg failure do?
predisposes to autoimmune, since Tregs help thymocytes recognize self.
the adult thymus is sucky and full of
adipocytes.
Whats darker on HE stain, medulla or cortex?
cortex.
NK cells last only
2 weeks.
helper T cells last
26 weeks
B cells can last from 10 days to ___ months.
15
Only 2% of thymocytes actually survive to mature. Why?
Worth the variety.
APCs that find antigen migrate to the nearest ____ to present its findings.
lymph node
If antigen recognized and B cell activated, B cell migrates to _____ and proliferates, forming a _____ and ____.
primary lymphoid nodule
germinal center, secondary lymphoid nodule
Capsule surrounding lymph node is made of
dense collagenous connective tissue.
B and T cells enter the _____ from endothelial venules.
paracortex.
from the paracortex, B cells migrate to ___ .
cortex
In the cortex, B cells form _____ and upon activation, form ___________.
primary lymphoid nodules
secondary lymphoid nodules, germinal centers
After secondary lymphoid, activated B cells go to _____ and exit via ____.
medulla
medullary sinuses and then efferent lymphatic vessel.
Where do plasma BBBBBBBBBBBBBBBBBBB cells go after leaving medulla??
????????????????
bone marrow to make Ab.
Memory BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBy cells go to ______
secondary lymph organs
APCs and DCs present antigen to T cells in what part of the lymph node? antigen presentation activates Th cells and stimulates ______.
paracortex.
proliferation.
Spherical aggregates of B cells located in the
cortex.
Where do B cells switch Ig class?
GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGerminal centers
B cells that dont make right sIg becomes
phagocytosed by macrophage
The dark zone of germinal center is for ___ and ___ of B cells.
clonal expansion and hypersomatic mutation
The light zone of a germinal center is for __ and __ for B cells.
selection, differentiation and class switching
What is the point of B and T cell exit of the lymph nodule
medullary sinus of the medulla.
What does the spleen do?
lymphoid cell proliferation
destroys aged platelets and erythrocytes
fetal hematopoeisis
The splenic artery enters at the ___
hilum
The ___ and ____ suspend the reticular connective tissue that forms architectural framework of spleen.
capsule and trabeculae.
Which pulp of the spleen is for filtration?
red pulp. macrophages and phagocytes take aged erythrocytes and platelets
Which pulp is for antigen presentation, t and B cell proliferation.
White.
What are the open circulation of red pulp called? closed circulation?
Open splenic cord of bilroth (spongy reticular)
closed splenic sinus (spaces)
B and T cells enter spleen via
marginal zone.
After the marginal zone, B and T cells migrate to the _____ of the ____ pulp.
PALS (central artery) of the White pulp.
Where do B cells go after PALS. what happens here.
lymph nodules (in spleen?) apc presentation, proliferation.
In the spleen, where is T cell APC presentation?
in PALS.
Where do B and T cells exit spleen??? Exit in lymph node?
via marginal sinuses in marginal zone.
via medullary sinus.
Marginal zone surrounds the
white pulp
What kinds of cells are in the marginal zone?
plasma cells, B and T cells, macrophages, Dc, apcs.
What are Peyers patches?
GALT. lymphoid follicles of ileum. B cells surrounded by T cells and APCs.
Where are M cells and what do they do?
epithelial lining of lymphoid follicles of GALT/BALT, capture antigens and give them to macrophages of Peyers patches etc.
Where is balt located?
Brochi
What are the invaginations of the palatine tonsil called?
crypts
Tonsils composed of incompletely encapsulated lymph nodules that guard pharynx from airborne antigen
yes.
