Lymph

Question 0

T or F. Lymph vessels and fenestrated.

Answer 0

No.

Question 1

Lymph vessels are a _____ layer of epithelial cells with an incomplete _______ lamina.

Answer 1

single

basal

Question 2

Causes of lymphedema.

Answer 2

Blockade of vessel due to
filiarisis tropical parasite
cellulitis
breast (lymph node dissection)

Question 3

Lymphangitis has bacterial growth so rapid that local and systemic tissue destruction includes

Answer 3

abscesses
cellulitis
septicemia
red streaks

Question 4

What are some components of innate immunity?

Answer 4

NK
neutrophils
macrophages
complement

Question 5

What can be described by specificity, diversity, memory, self/nonself recognition?

Answer 5

Adaptive immunity.

Question 6

What is the order of Igs made in response to stimulus?

Answer 6

MADGE

Question 7

What’s special about IgM?

Answer 7

isotope formed in primary response

Question 8

IgA is a _______ antibody in tears, salive, gut, nasal.

Answer 8

secretory.

Question 9

what does IgD activate?

Answer 9

B cells.

Immunoglobulin Dave activates Buster.

Question 10

Which Ig is most common and is for opsonization for NK?

Answer 10

IgG

Question 11

what does IgE do?

Answer 11

for degranulate mast and basophil

beeeeeeeeeeeeeeeeeeeeeeeeeeees

Question 12

what are the primary lymphoid organs?

Answer 12

Thymus, bone marrow

Question 13

What are the secondary lymphoid organs?

Answer 13

Lymph nodes, spleen, malt

Question 14

Which are the encapsulated lymph organs?

Answer 14

thymus, spleen, lymph nodes.

Question 15

Thymocytes enter the _____ via the ______.

Answer 15

cortex

corticomedullary junction of trabeculae.

Question 16

Cortex contains what types of cells?

Answer 16

macrophages, apcs, epithelial reticular cells.

Question 17

What is positive and negative selection of thymocytes in thymus?

Answer 17

positively select for those that can recognize mhc 1 and 2

negatively select for self recognition

Question 18

immunocompetent naive T cells migrate out of the medulla via

Answer 18

venues and efferent lymphatic vessels

Question 19

The medulla is characterized by

Answer 19

hassalls corpuscles

Question 20

Maturation of thymocytes in cortex stimulated by hormones of

Answer 20

epithelial reticular cells

Question 21

T or F. Thymoctytes leave the cortex as naive, immunocompetent mature T cells.

Answer 21

True.

Question 22

What isolates thymocytes from exposure to antigens/blood borne macromolecules?

Answer 22

blood thymus barrier

Question 23

What does a Treg failure do?

Answer 23

predisposes to autoimmune, since Tregs help thymocytes recognize self.

Question 24

the adult thymus is sucky and full of

Answer 24

adipocytes.

Question 25

Whats darker on HE stain, medulla or cortex?

Answer 25

cortex.

Question 26

NK cells last only

Answer 26

2 weeks.

Question 27

helper T cells last

Answer 27

26 weeks

Question 28

B cells can last from 10 days to ___ months.

Answer 28

15

Question 29

Only 2% of thymocytes actually survive to mature. Why?

Answer 29

Worth the variety.

Question 30

APCs that find antigen migrate to the nearest ____ to present its findings.

Answer 30

lymph node

Question 31

If antigen recognized and B cell activated, B cell migrates to _____ and proliferates, forming a _____ and ____.

Answer 31

primary lymphoid nodule | germinal center, secondary lymphoid nodule

Question 32

Capsule surrounding lymph node is made of

Answer 32

dense collagenous connective tissue.

Question 33

B and T cells enter the _____ from endothelial venules.

Answer 33

paracortex.

Question 34

from the paracortex, B cells migrate to ___ .

Answer 34

cortex

Question 35

In the cortex, B cells form _____ and upon activation, form ___________.

Answer 35

primary lymphoid nodules | secondary lymphoid nodules, germinal centers

Question 36

After secondary lymphoid, activated B cells go to _____ and exit via ____.

Answer 36

medulla | medullary sinuses and then efferent lymphatic vessel.

Question 37

Where do plasma BBBBBBBBBBBBBBBBBBB cells go after leaving medulla??

Answer 37

???????????????? | bone marrow to make Ab.

Question 38

Memory BBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBy cells go to ______

Answer 38

secondary lymph organs

Question 39

APCs and DCs present antigen to T cells in what part of the lymph node? antigen presentation activates Th cells and stimulates ______.

Answer 39

paracortex. | proliferation.

Question 40

Spherical aggregates of B cells located in the

Answer 40

cortex.

Question 41

Where do B cells switch Ig class?

Answer 41

GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGerminal centers

Question 42

B cells that dont make right sIg becomes

Answer 42

phagocytosed by macrophage

Question 43

The dark zone of germinal center is for ___ and ___ of B cells.

Answer 43

clonal expansion and hypersomatic mutation

Question 44

The light zone of a germinal center is for __ and __ for B cells.

Answer 44

selection, differentiation and class switching

Question 45

What is the point of B and T cell exit of the lymph nodule

Answer 45

medullary sinus of the medulla.

Question 46

What does the spleen do?

Answer 46

lymphoid cell proliferation destroys aged platelets and erythrocytes fetal hematopoeisis

Question 47

The splenic artery enters at the ___

Answer 47

hilum

Question 48

The ___ and ____ suspend the reticular connective tissue that forms architectural framework of spleen.

Answer 48

capsule and trabeculae.

Question 49

Which pulp of the spleen is for filtration?

Answer 49

red pulp. macrophages and phagocytes take aged erythrocytes and platelets

Question 50

Which pulp is for antigen presentation, t and B cell proliferation.

Answer 50

White.

Question 51

What are the open circulation of red pulp called? closed circulation?

Answer 51

Open splenic cord of bilroth (spongy reticular) | closed splenic sinus (spaces)

Question 52

B and T cells enter spleen via

Answer 52

marginal zone.

Question 53

After the marginal zone, B and T cells migrate to the _____ of the ____ pulp.

Answer 53

PALS (central artery) of the White pulp.

Question 54

Where do B cells go after PALS. what happens here.

Answer 54

lymph nodules (in spleen?) apc presentation, proliferation.

Question 55

In the spleen, where is T cell APC presentation?

Answer 55

in PALS.

Question 56

Where do B and T cells exit spleen??? Exit in lymph node?

Answer 56

via marginal sinuses in marginal zone. | via medullary sinus.

Question 57

Marginal zone surrounds the

Answer 57

white pulp

Question 58

What kinds of cells are in the marginal zone?

Answer 58

plasma cells, B and T cells, macrophages, Dc, apcs.

Question 59

What are Peyers patches?

Answer 59

GALT. lymphoid follicles of ileum. B cells surrounded by T cells and APCs.

Question 60

Where are M cells and what do they do?

Answer 60

epithelial lining of lymphoid follicles of GALT/BALT, capture antigens and give them to macrophages of Peyers patches etc.

Question 61

Where is balt located?

Answer 61

Brochi

Question 62

What are the invaginations of the palatine tonsil called?

Answer 62

crypts

Question 63

Tonsils composed of incompletely encapsulated lymph nodules that guard pharynx from airborne antigen

Answer 63

yes.