Lymph Flashcards
Sites of production and maturation of immune cells
equates to military school
Primary Lymphoid organs
Potential sites for contact with foreign antigens
Site of mature lymphocyte harbor
where foreign antigens activate lymphocytes
equates to field bases
Secondary Lymphoid organs
“Site of development for all hematopoietic stem cells (myeloid/lymphoid lines)
Primary lymphoid organ
Bone marrow
“Site of maturation and selection of T lymphocytes
Primary lymphoid organ “
Thymus
what are the secondary lymphoid organs
Spleen, Lymph nodes, Mucosal-associated lymphoid tissue (MALT)
“Largest secondary lymphoid organ
made of two main types of tissue “
Spleen
Functions of the tissue in the Spleen
“Red pulp - destroy old RBCs
White pulp - contains the lymphoid tissue, drains antigens from blood “
“Function - filtration; generation of memory B-cells
central collecting points for lymph fluid from adjacent tissues
secondary lymphoid organ “
Lymph Nodes
“Section of the Lymph Node that contains b cells that are organized in follicles
outermost section in the lymph node “
Cortex of Lymph Node
“Section of the Lymph Node that contains mostly T cells and some DCs
found between the other two sections of the lymph node”
Paracortex of the Lymph Node
“Section of the Lymph Node that contains Macrophages/DCs
innermost section in the lymph node “
Medulla of the Lymph Node
Filtrate of tissue fluids
Lymph fluid
Flow of lymph through the lymph node
Afferent lymphatics, medullary cords, efferent lymphatics
How do Lymphocytes enter the Lymph Node from the bloodstream
means of specialized high endothelial venules, located in paracortical areas
Flow of antigens through the Lymph Node
1 - in via the afferent lymphatic
2 - DCs and Macs in medulla present antigen
3 - DCs activate T cells that are in the paracortex
4 - Activated T cells give signals to promote cognate B cell proliferation in the follicles
