lupus nephritis

Question 1

how can lupus present in the kidney

Answer 1

diffuse proliferative GN, focal proliferative, immune complex mediated interstitial nephritis, membranous nephropathy, mesangial proliferative GN.

Question 2

how many classifications and what are they?

Answer 2

I: normal glomeruli by LM,
II: pure mesangiopathic
III: foacl GN
IV: diffuse GN
V: membranous 
VI: advanced sclerosis

Question 3

what are the worst prognoses?

Answer 3

diffuse is the worse, focal is next to worst

Question 4

what is the focus on lupus prognosis?

Answer 4

activity and chronicity. the activity defines the treatment and the chronicity defines the prognosis

Question 5

what is a classic histology for LN

Answer 5

wire loops and fibrin thrombi

Question 6

what are the wire loop deposits in lupus?

Answer 6

IgG

Question 7

what renal lesions suggest lupus?

Answer 7

full house immune complex deposits. deposits in all locations. tubuloreticular structures in endothelial cells with a fingerprint substructure to these deposits.