kidney involvement in systemic disease quick associations

Question 1

renal path associations with SLE

Answer 1

immune complex glomerulonephritis, immune interstitial nephritis, lupus vasculopathy

Question 2

renal path associations with scleroderma

Answer 2

microangiopathic lesions similar to malignant hypertension.

Question 3

renal path associations with RA

Answer 3

AA-amyloidosis, controversial - (mesangioproliferative with isolated hematuria, pANCA -necrotizing crescentic GN, membranous).

Question 4

renal path associations with RA drugs

Answer 4

MCD from NSAIDs, membranous nephropathy from gold or penicillamine, immune phenomena from anti-TNF agents.

Question 5

renal path associations with sjogrens

Answer 5

chronic tubulointerstitial nephritis with tubular syndrome.

Question 6

renal path associations with mixed connective tissue disease

Answer 6

immune complex glomerulonephropathy

Question 7

renal path associations with antiphospholipid syndrome

Answer 7

thrombotic microangiopathy

Question 8

renal path associations with chronic hepatitis B

Answer 8

classic polyarteritis nodosa, membranous immune complex GN

Question 9

renal path associations with hepatitis C

Answer 9

cryogammaglobinemia, membranoproliferative immune complex glomerulopathy

Question 10

renal path associations with bacterial endocarditis

Answer 10

immune complex GN

Question 11

renal path associations with malaria

Answer 11

various patterns of immune complex GN

Question 12

renal path associations with schistomiasis

Answer 12

membranoproliferative immune complex GN

Question 13

renal path associations with syphilis

Answer 13

membranous immune complex GN

Question 14

renal path associations with HIV/AIDS

Answer 14

collapsing GN

Question 15

renal path associations with DM

Answer 15

glomerulopathy with nephrosis and progressive renal failure, accelerated atherosclerosis, prominent arteriolosclerosis, papillary necrosis, pyelonephritis

Question 16

renal path associations with amyloidosis

Answer 16

glomerular and vascular deposition causing nephrotic syndrome and progressive renal insufficiency

Question 17

renal path associations with vasculitis

Answer 17

PAN, wegeners, churg-strauss, microscopic polyangiitis, henoch-shonlein purpura, good-pastures

Question 18

renal path associations with atheromatous renal disease

Answer 18

renal artery stenosis, chronic ischemic nephropathy, atheroembolic renal failure, renal infarction

Question 19

renal path associations with multiple myeloma/paraproteinemia

Answer 19

hypercalcemia-mediated ARF, tubular toxicity, cast nephropathy, amyloid, light chain nephropahty, type I cryoglobinemic.

Question 20

pulmonary-renal syndromes

Answer 20

good-pastures, granulomatous with polyangiitis or microscopic polyangiitis (pauci-immune crescentic)

Question 21

cardio-renal syndrome

Answer 21

multifactorial bidirectional exacerbation of heart and kidney dysfunction

Question 22

hepato-renal syndrome

Answer 22

intractable renal failure with prerenal azotemia

Question 23

type I cryogammaglobinemia

Answer 23

monoclonal, waldenstroms macrogammaglobinemia or multiple myeloma

Question 24

type II cryogammaglobinemia

Answer 24

monoclonal RF IgM kappa. hepatitis C infection

Question 25

type III cryogammaglobinemia

Answer 25

polyclonal immunoglobulin with an anti globulin against polyclonal gammaglobulin of different serotype. autoimmune and inflammatory disorders.

Question 26

what drugs are associated with MCD

Answer 26

NSAIDs

Question 27

what drugs are associated with focal segmental GS

Answer 27

anabolic androgenic steroids

Question 28

what drugs are associated with membranous GN?

Answer 28

gold, penicillamine, captopril and NSAIDs (RA drugs)

Question 29

what drugs are associated with collapsing GN

Answer 29

pamidronate, interferons

Question 30

what drugs are associated with ANCA-assocaited necrotizing GN

Answer 30

hydralazine, propylthiouracil, cocaine adulterated with levamisole

Question 31

what drugs are associated with hemodynamically induced renal failure

Answer 31

anything that undermines the auto regulation of the kidney: ACEi, NSAIDs.

Question 32

what drugs are associated with ATN

Answer 32

aminoglycosides, synthetic cannabinoids, cocaine (rhabdomyolysis and subsequent kidney failure)

Question 33

what drugs are associated with acute interstitial nephritis

Answer 33

allergic reactions most commonly beta-lactam antibiotics and PPI

Question 34

what drugs are associated with intrerenal tubular destruction

Answer 34

indinavir

Question 35

what drugs are associated with chronic tubulointerstitial fibrosis

Answer 35

lithium, aristolochic acid

Question 36

what drugs are associated with thrombotic microangiopahty

Answer 36

cyclosporin A, mtomycin C

Question 37

what drugs are associated with papillary necrosis

Answer 37

analgesic abuse