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pathology unit 5 > kidney involvement in systemic disease quick associations > Flashcards

kidney involvement in systemic disease quick associations Flashcards

1
Q

renal path associations with SLE

A

immune complex glomerulonephritis, immune interstitial nephritis, lupus vasculopathy

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2
Q

renal path associations with scleroderma

A

microangiopathic lesions similar to malignant hypertension.

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3
Q

renal path associations with RA

A

AA-amyloidosis, controversial - (mesangioproliferative with isolated hematuria, pANCA -necrotizing crescentic GN, membranous).

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4
Q

renal path associations with RA drugs

A

MCD from NSAIDs, membranous nephropathy from gold or penicillamine, immune phenomena from anti-TNF agents.

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5
Q

renal path associations with sjogrens

A

chronic tubulointerstitial nephritis with tubular syndrome.

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6
Q

renal path associations with mixed connective tissue disease

A

immune complex glomerulonephropathy

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7
Q

renal path associations with antiphospholipid syndrome

A

thrombotic microangiopathy

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8
Q

renal path associations with chronic hepatitis B

A

classic polyarteritis nodosa, membranous immune complex GN

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9
Q

renal path associations with hepatitis C

A

cryogammaglobinemia, membranoproliferative immune complex glomerulopathy

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10
Q

renal path associations with bacterial endocarditis

A

immune complex GN

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11
Q

renal path associations with malaria

A

various patterns of immune complex GN

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12
Q

renal path associations with schistomiasis

A

membranoproliferative immune complex GN

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13
Q

renal path associations with syphilis

A

membranous immune complex GN

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14
Q

renal path associations with HIV/AIDS

A

collapsing GN

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15
Q

renal path associations with DM

A

glomerulopathy with nephrosis and progressive renal failure, accelerated atherosclerosis, prominent arteriolosclerosis, papillary necrosis, pyelonephritis

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16
Q

renal path associations with amyloidosis

A

glomerular and vascular deposition causing nephrotic syndrome and progressive renal insufficiency

17
Q

renal path associations with vasculitis

A

PAN, wegeners, churg-strauss, microscopic polyangiitis, henoch-shonlein purpura, good-pastures

18
Q

renal path associations with atheromatous renal disease

A

renal artery stenosis, chronic ischemic nephropathy, atheroembolic renal failure, renal infarction

19
Q

renal path associations with multiple myeloma/paraproteinemia

A

hypercalcemia-mediated ARF, tubular toxicity, cast nephropathy, amyloid, light chain nephropahty, type I cryoglobinemic.

20
Q

pulmonary-renal syndromes

A

good-pastures, granulomatous with polyangiitis or microscopic polyangiitis (pauci-immune crescentic)

21
Q

cardio-renal syndrome

A

multifactorial bidirectional exacerbation of heart and kidney dysfunction

22
Q

hepato-renal syndrome

A

intractable renal failure with prerenal azotemia

23
Q

type I cryogammaglobinemia

A

monoclonal, waldenstroms macrogammaglobinemia or multiple myeloma

24
Q

type II cryogammaglobinemia

A

monoclonal RF IgM kappa. hepatitis C infection

25
Q

type III cryogammaglobinemia

A

polyclonal immunoglobulin with an anti globulin against polyclonal gammaglobulin of different serotype. autoimmune and inflammatory disorders.

26
Q

what drugs are associated with MCD

A

NSAIDs

27
Q

what drugs are associated with focal segmental GS

A

anabolic androgenic steroids

28
Q

what drugs are associated with membranous GN?

A

gold, penicillamine, captopril and NSAIDs (RA drugs)

29
Q

what drugs are associated with collapsing GN

A

pamidronate, interferons

30
Q

what drugs are associated with ANCA-assocaited necrotizing GN

A

hydralazine, propylthiouracil, cocaine adulterated with levamisole

31
Q

what drugs are associated with hemodynamically induced renal failure

A

anything that undermines the auto regulation of the kidney: ACEi, NSAIDs.

32
Q

what drugs are associated with ATN

A

aminoglycosides, synthetic cannabinoids, cocaine (rhabdomyolysis and subsequent kidney failure)

33
Q

what drugs are associated with acute interstitial nephritis

A

allergic reactions most commonly beta-lactam antibiotics and PPI

34
Q

what drugs are associated with intrerenal tubular destruction

A

indinavir

35
Q

what drugs are associated with chronic tubulointerstitial fibrosis

A

lithium, aristolochic acid

36
Q

what drugs are associated with thrombotic microangiopahty

A

cyclosporin A, mtomycin C

37
Q

what drugs are associated with papillary necrosis

A

analgesic abuse

pathology unit 5 (10 decks)

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