Lupus Flashcards
what is the most common type of Lupus?
systemic lupus erythematous
chronic long-lasting autoimmune disease causing widespread inflammation and tissue damage involving multiple organs
systemic lupus erythematous
which ethnicity is SLE most common in?
African Americans
which patients is SLE most common in?
females in childbearing years
which condition can occur with SLE?
rheumatoid arthritis
what are 3 constitutional symptoms of SLE?
fever
fatigue
weight changes
what 4 cutaneous symptoms can occur in SLE?
malar/butterfly rash (over cheeks and nose)
photosensitivity
oral/nasal ulcers
alopecia
what 2 MSK symptoms occur in SLE?
arthralgias
arthritis (non-erosive)
what is the most common pulmonary finding in SLE?
pleuritis
involvement of what system in SLE indicates a worse prognosis?
CNS
what is the ACR criteria to diagnose SLE?
4/11
Serositis
Oral ulcers
Arthritis
Photosensitivity
Blood disorders
Renal
ANA +
Immunologic
Neurologic
Malar rash
Discoid rash
acute cutaneous lupus erythematosus that is also known as butterfly rush, sharply demarcated, flat/raised, and not itchy
malar rash
chronic cutaneous lupus erythematous that is disc shaped; raised erythematous plaques with adherent keratotic scales on the scalp, face, neck, or oral cavity. Presents with a ring around the lesions
discoid rash/lupus
skin rash as a result of unusual reaction to sunlight, UVA< UVB, or visible light; occurs more than 1 week after sun exposure, can exacerbate systemic symptoms
photosensitivity
what is recommended to patients with SLE for photosensitivity?
sun screen
painless oral or nasal occurrences in SLE
ulcers
where in the body is discoid lupus painful?
oral cavity
what lab is found in over half of patients with SLE?
lymphopenia
lab finding that correlates with disease activity, anemia, and renal disease in SLE
ESR
patients with SLE with serositis or infection will lead to an increase in which lab?
CRP
which lab can rule out SLE if negative?
ANA
which 2 labs can rule in SLE?
anti-smith
anti-dsDNA
which lab will indicate drug-induced lupus?
anti-histone antibody
which 2 labs will indicate neonatal lupus?
anti-Ro/SSA
anti-La/SSB
how will complements be affected in SLE?
decreased
what will be found in urinalysis in SLE? (2)
proteinuria
hematuria
what is the management/treatment for SLE? (3)
NSAIDS (arthralgia)
steroids (exacerbations)
hydroxychloroquine (long-term)
what is the treatment for active glomerulonephritis?
cytotoxic agents
what exam should be done every year when diagnosed with SLE?
visual exam for risk of retinal toxicity
