Lupus Flashcards
What type of hypersensitivity reaction is SLE?
III
What are the epidemiological factors for SLE?
- African-American, Hispanic, Asian and Native American ethnicities
- Women
- 20-40yrs
What are the features of SLE by body system?
General o Fatigue o Fever o Mouth ulcers o Lymphadenopathy o Weight loss
Skin o Photosensitive malar rash – butterfly rash o Discoid rash o Raynaud’s phenomenon o Alopecia
MSK
o Arthralgia
CV
o Pericarditis, myocarditis and endocarditis
Respiratory
o Pleuritis
Renal
o Proteinuria
o Glomerulonephritis (diffuse proliferative glomerulonephritis)
Neuropsychiatric
o Seizures
o Psychosis
o Anxiety and depression
What blood test do you do for SLE?
- CRP/ESR
- C3, C4 (low)
- ANA
- anti-Smith
- dsDNA
Which antibody is specific for SLE?
ANA
What happens to CRP and ESR in SLE?
CRP stays normal
ESR increases with active SLE
What are the complications of SLE?
- HTN, CAD, Libman-Sacks endocarditis
- Osteoporosis
- Kidney disease
- Antiphospholipid syndrome
- Haematological disorders
- Optic neuritis, transverse myelitis and psychosis
What antibodies do you check for in pregnant women with SLE and why?
Ro (anti-SSA) and LA (anti-SSB)
- Able to cross the plcenta
How do you manage SLE?
- NSAIDs
- Steroids
- Hydroxychloroquine
- Sun cream and sun avoidance
What is discoid lupus erythematous?
Non-cancerous chronic skin condition that can occur in the absence of systemic features
What is the presentation of discoid lupus erythematous?
• Lesions o On face, ears and scalp o Photosensitive o Well demarcated and scaling • Scarring alopecia • Hyper/hypo-pigmented scars
What is the management of discoid lupus erythematous?
- Sun protection
- Topical steroids
- Intralesional steroid injections
- Hydroxychloroquine
