Lung Tumors-Prager Flashcards

1
Q

What portion of lung cancers occur in smokers?

A

80-90%, 60x risk for 40 pack years compared to nonsmokers

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2
Q

What are molecular genetic markers for lung cancer

A

– 3p deletion, one of the most consistent chromosomal
abnormalities in lung cancer: loss of the short arm of
chromosome 3
– Mutation of oncogenes (K-ras, Endothelial growth
factor receptor-pill blocks effects)
– Deletion and/or mutation in tumor suppressor genes
(p53)
– Telomerase activity increase (restores length of
chromosome—immortal cells

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3
Q

What are the classifications of lung tumors/malignant epithelial tumors?

A

Carcinoids/atypical carcinoids, small cell carcinoma (18%), nonsmall cell carcinoma: large cell CA (9%), squamous CA (30%), adenocarcinoma (31%): bronchioloalveolar, various subtypes.

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4
Q

Adenocarcinoma in lungs

A

• Most common type of carcinoma in nonsmokers and in women
• More often peripheral than central
• Small tumors can be associated with nodal
and distant metastases
• Must distinguish primary from metastatic

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5
Q

Bronchioloalveolar cell carcinoma (BAC)
Adenocarcinoma in-situ

A

• Mucous-secreting or non-mucinous
adenocarcinomas that line alveolar spaces
• Often multicentric making resectional cure
unlikely or impossible (can excise 1 but not 4 tumors)
• May be indolent with slow progression over years (can live with for years without death)
• Infrequently metastasizes outside chest
• May be confused with pneumonia on chest x ray

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6
Q

Squamous cell carcinoma in the lung

A

• Often bulky, large tumors of bronchogenic
origin, that invade adjacent structures; faster
doubling time than adenocarcinoma
• Usually arise in mainstem or lobar bronchi,
often visualized bronchoscopically
• Metastasis in relation to tumor size may
occur later than adenocarcinoma
• May cavitate due to central necrosis

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7
Q

Large cell carcinoma in lungs

A

No differentiation twoards squamous or adenocarcinoma

Aggressive, poor prognosis

If US exam, many show glandular or squamous differentiation

Separated out because high grade and poor prognosis

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8
Q

Small Cell Carcinoma in the lung

A

• Increasing in frequency (25% of lung Ca)
• 99% occur in smokers
• Usually centrally located and disseminated
at time of diagnosis; surgery not an option
• May be very responsive to chemotherapy
with 15-20% cure in limited disease—but
only a fraction of patients present that way
• May secrete biologically active peptides

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9
Q

Which lung cancers are centrally located and which are peripheral?

A

Central: Squamous cell, small cell carcinoma, carcinoid

Peripheral: adenocarcinoma

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10
Q

Clinical Presentation of Lung Cancers

A

• Endobronchial tumor: persistent cough;
hemoptysis; fixed wheeze (if in mainstem bronchus) or stridor; postobstructive pneumonia; weight loss
• Peripheral tumor: often asymptomatic until local
invasion or metastases cause symptoms
• Chest pain; dyspnea; brain metastases (seizures,
neurologic deficits); bone mets (pain, pathologic
fractures, hypercalcemia)

• Hoarseness from left vocal cord paralysis
from damage to L recurrent laryngeal nerve
• Superior vena cava syndrome- face swells from lack of venous return
• Obstructed bronchus causing cough,
wheeze, pneumonia, atelectasis, bleeding

Dyspnea

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11
Q

Where are the most common sites for lung cancer metastasis?

A

brain (CVA, seizure);
bone (pain, pathologic fracture, spinal cord
compression); liver (pain, jaundice);
adrenal glands

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12
Q

What are the considerations for screening with CXR or CT scan?

A

CXR is not sensitive enough and CT scans are too sensitive, with too many false positives.

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13
Q

Methods of tissue diagnosis of lung cancer

A

– Flexible bronchoscopy (endobronchial tumor)
– Transthoracic CT-guided needle biopsy (peripheral
lesions)
– Thoracentesis
– Open lung biopsy (Video-assisted thoracoscopy)-like laproscopy
– Peripheral node, mass; liver biopsy; brain biopsy
– Sputum cytology

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14
Q

What are the criteria for staging of lung cancer

A

• T—tumor size, location, invasion
• N—nodal involvement
• M—metastases within and outside the
thorax

T1-T4 in cm

N0-N3 from no nodes to contralateral or mediastinal or supraclavicular nodes

M0 or M1 for metastases

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15
Q

Survival based on staging

A

Best prognosis: Stage IA (T1, N0, M0): 75% 5 year survival

Worst prognosis: Stage IV (M1): <20% survival after even 1 year

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16
Q

How is lymph node staging done?

A

• CT scan
• Positron Emission Tomography (PET) scan
more sensitive and specific than CT—very
expensive (moreradionucleated glucose means more malignant reactivity)
• Flexible bronchoscopy—Transbronchial
needle aspiration-guided by ultrasound
• Mediastinoscopy—most sensitive and
specific for mediastinal node (U shaped incision at suprasternal notch)

17
Q

What imaging tests are done for staging?

A

CT, PET, MRI to rule out brain metastasis.

18
Q

Treatment of NSCLC

A

• Stage I, II: Resection—lobe(s), or entire
lung; adjuvant chemotherapy for IB or more
• Stage IIIa: neoadjuvant
chemotherapy (try to convert inoperable situatino into operable) + radiation, and if excellent
tumor response, follow with surgery
• Stage IIIb: chemotherapy +/- radiation
• Stage IV: chemotherapy

19
Q

What is the treatment of small cell lung cancer?

A

Never surgery

  • Limited: chemotherapy + radiation (prevent spreading)
  • Extensive: chemotherapy

Treat effects of tumor (gene effects by tumor markers: ex: EGFR with tyrosine kinase inhibitors)

20
Q

Malignant Pleural Effusion

A

• Common, difficult to treat complication of
primary and metastatic lung cancer
• Symptoms: dyspnea, chest pain
• Treatment: Thoracentesis for diagnosis; for
defintive treatment chest tube or VATS with
pleurodesis
– talcum powder-saline suspension in pleural space to
cause pleural inflammation and scarring leading to
adhesion of pleural surfaces
– Occasional chemotherapy into pleural spac

21
Q

Malignant Mesothelioma

A

• Malignant tumor of pleural mesothelium
• High association with prior asbestos exposure—
even if decades before
• Usually fatal—infrequent cures require radical
resection of entire lung and pleura followed by
chemoRx
• Improving efficacy of palliative chemoRx
• Often presents with pain and/or pleural effusion
• May involve abdominal mesothelium

22
Q

Bronchial Carcinoid

A

• Malignant neoplasm of neuroendocrine cell origin
• Can be central or peripheral; when endobronchial may
present with hemoptysis or post obstructive pneumonia
• Tumor of low grade malignancy—if unresected may take
years to metastasize to regional nodes or extrathoracic sites
• 1-5% of all lung tumors—unrelated to smoking
• Composed of uniform small cells; EM shows
neurosecretory granules
• Excellent prognosis if resected

23
Q

Evaluation of Solitary Pulmonary
Nodule

A

• Common clinical problem: benign or malignant?
• Benign etiology suggested by
– Small nodule (<1cm), smooth margin
– Young patient
– Non-smoker
• Old chest films critically important
• Evaluate with chest CT +/- PET; occasional need
for biopsy (bronchoscopy, needle asptn.), surgery
• Often can be followed with repeat imaging studies
to check for growth