LTP - Learning & Memory Flashcards
Types of memory
declarative and non-declarative, long and short term
What occurs at the active zone
synaptic transmission
Function of SNAREs
drive synaptic vesicles close to membrane
What is the most important receptor for neurotransmission
AMPA receptor
Why is AMPA important for neurotransmission
most permeable for sodium and potassium
Function of AMPA receptors
aids depolarisation
What is NDMA more permeable for
calcium
What simple systems are used to study learning and memory
snails, worms, insects and cockroaches
Function of habituation
allows NS to stop responding to repetitive stimulus thats not interesting
Sensitisation
NS responds more and more
Associated learning is a
form of sensitisation
Examples of habituation
eye blink reflex, visual attention, emotional response
What does the gill contain in aplysia
precisely defined sensory neurons
Repeated touch of aplysia
habituation - reduces gill withdrawal reflex
What does habituation result from
reduced synaptic strength, reduced transmitter release
What does sensitisation involve
increased gill withdrawal reflex, presynaptic input from sensory neurons
What models models mechanism of sensitisation
simple bear model
Simple bear model
pkA phosphorylates and inactivates K+ channels, longer depolarisation
What is the effect of longer depolarisation
more vesicular release, increased response of post synaptic neuron
Habituation depletes the
synaptic vesicle pool
Sensitisation involves ?
serotonin-ergic feedback from other sensory neuron
Type of associative learning
pavlovian conditioning
What are the complex models of sensitisation and learning
multiple intracellular signalling pathways, varying activation thresholds
