LTP - Learning & Memory

Question 1

Types of memory

Answer 1

declarative and non-declarative, long and short term

Question 2

What occurs at the active zone

Answer 2

synaptic transmission

Question 3

Function of SNAREs

Answer 3

drive synaptic vesicles close to membrane

Question 4

What is the most important receptor for neurotransmission

Answer 4

AMPA receptor

Question 5

Why is AMPA important for neurotransmission

Answer 5

most permeable for sodium and potassium

Question 6

Function of AMPA receptors

Answer 6

aids depolarisation

Question 7

What is NDMA more permeable for

Answer 7

calcium

Question 8

What simple systems are used to study learning and memory

Answer 8

snails, worms, insects and cockroaches

Question 9

Function of habituation

Answer 9

allows NS to stop responding to repetitive stimulus thats not interesting

Question 10

Sensitisation

Answer 10

NS responds more and more

Question 11

Associated learning is a

Answer 11

form of sensitisation

Question 12

Examples of habituation

Answer 12

eye blink reflex, visual attention, emotional response

Question 13

What does the gill contain in aplysia

Answer 13

precisely defined sensory neurons

Question 14

Repeated touch of aplysia

Answer 14

habituation - reduces gill withdrawal reflex

Question 15

What does habituation result from

Answer 15

reduced synaptic strength, reduced transmitter release

Question 16

What does sensitisation involve

Answer 16

increased gill withdrawal reflex, presynaptic input from sensory neurons

Question 17

What models models mechanism of sensitisation

Answer 17

simple bear model

Question 18

Simple bear model

Answer 18

pkA phosphorylates and inactivates K+ channels, longer depolarisation

Question 19

What is the effect of longer depolarisation

Answer 19

more vesicular release, increased response of post synaptic neuron

Question 20

Habituation depletes the

Answer 20

synaptic vesicle pool

Question 21

Sensitisation involves ?

Answer 21

serotonin-ergic feedback from other sensory neuron

Question 22

Type of associative learning

Answer 22

pavlovian conditioning

Question 23

What are the complex models of sensitisation and learning

Answer 23

multiple intracellular signalling pathways, varying activation thresholds