1
Q

Three types of Bronchitis are

A

Acute
Chronic
Bronchiolitis

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2
Q

Types of Pneumonia

A

Aspiration
HCAP
HAP-VAP
CAP

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3
Q

What is pneumonia

A

Pneumonia is an infection of the lungs that leads to consolidation of the normally air filled alveoli. It can be an infection in one or both of the lungs and can be caused by bacteria, viruses, fungus, or chemical irritants. It causes air sacs to be filled with pus or fluid.


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4
Q

CAP

A

Community acquired pneumonia is the most common type of pneumonia. It is defined as a pneumonia that developed in the outpatient setting in patients who have not been in any healthcare facilities. This includes wound care or dialysis clinics.

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5
Q

HAP and VAP

A

Hospital acquired pneumonia occurs in a patient who is been admitted and develops pneumonia 48 hours or more after admission.
VAP-A type of hospital acquired pneumonia that is common is ventilator associated pneumonia. This is for patients who are endotracheal intubated and develop pneumonia 48 to 72 hours after intubation.

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6
Q

HCAP

A

pneumonia occurring in any hospitalized patient for at least two days within 90 days of the onset of the infection. This includes patients who reside in a nursing home or long-term care facility, and any patients who have recently received IV antibiotic therapy, wound care, or chemotherapy within the last 30 days or patients who attend a hemodialysis clinic regularly.


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7
Q

Other classifications of PNA

A

Other ways to classify pneumonia is based on causation. Different causes of pneumonia can include aspiration pneumonia, chemical pneumonia, eosinophilic pneumonia, bronchiolitis obliterans organizing pneumonia, necrotizing pneumonia, severe acute respiratory syndrome, or opportunistic pneumonias.


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8
Q

Classification of PNA in location

A

Pneumonias can also be classified based on the area of the lung where they occur. Lobar pneumonias affect only a single lobe. Multi-lobar pneumonias affect multiple lobes. Bronchial pneumonia affects the bronchi or bronchioles, and interstitial pneumonia affects the areas between the alveoli.


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9
Q

Patho of PNA

A

Pneumonia occurs when organisms gain access to the lower respiratory tract that is usually sterile by being inhaled, entering from the blood stream from an extra pulmonary site of infection, or through aspiration. Viral lung infections can suppress a bacterial clearing in the lungs, thus increasing the risk for a secondary bacterial pneumonia. A majority of pneumonias are community acquired in otherwise healthy adults.


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10
Q

CAP: Primary pathogens

A

Streptococcus pneumonia. It contributes to approximate 75% of the cases seen. This pathogen colonizes the nasopharyngeal flora in up to 50% of healthy adults.

Other common causes are mycoplasma pneumonia and H influenza

Haemophilus influenza is seen in a higher rate in patients with COPD and is usually a colonizer in patients with cystic fibrosis.

Staph aureus pneumonia is more likely to be seen in elderly patients, particularly those who reside in a long-term care facility.

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11
Q

Viruses cause about ___ percent of PNA. These pathogens are ____, ____,___,___.

A

10-15 percent

include influenza, parainfluenza, RSV, and adenovirus.


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12
Q

Causative agent for HAP

A

causative agents for hospital associated pneumonia are gram-negative aerobic bacilli or Staphylococcus aureus.

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13
Q

Causative agent for VAP

A

ventilator associated pneumonia is more likely to be resistant enteric gram-negative bacilli, Pseudomonas aeruginosa, or Acinetobacter species.

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14
Q

Causative agent(S) for aspiration PNA

A

Anaerobic bacteria are the more likely cause of an aspiration pneumonia.

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15
Q

PNA in pediatrics

A

In the pediatric population you’re more likely to see pneumonia caused by a virus, particularly RSV, parainfluenza, or adenovirus.


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16
Q

Risk factors for PNA

A

Risk factors include children younger than two or adults greater than 65, having a chronic lung disease, or being an immune compromised host. Having a neuromuscular weakness that causes an inability to cough is also a risk factor. Other risk factors include increased alcohol or tobacco abuse, malnutrition, frequent exposure to certain irritants, advanced cardiac disease, or mechanical ventilation.


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17
Q

Clinical presentation of PNA

A

Your patient will likely complain of fever, chills, dyspnea, a productive cough, hemostasis, pleuritic chest pain, and confusion and lethargy is usually seen in the elderly. On physical exam you might find tachypnea and tachycardia, dullness to percussion or diminished breath sounds over the affected area, chest wall retractions, or inspiratory crackles on auscultation.


18
Q

PNA diagnostics

A

Diagnosis is made based on clinical presentation, history, and chest x-ray. In order to diagnose pneumonia, you must see and infiltrate on radiographic findings. Other diagnostic test might include a CBC but it is not necessary for diagnosis they can help further confirm. You might see leukocytosis or bands. Renal function in order to appropriately dose of medication or oxygen levels via pulse oximetry or ABG might also be done.


Elevated lymphocytes in viral
predominance of neutrophils for bacterial

19
Q

PNA diagnostics, cont

A

Some other diagnostic tests. Sputum cultures are not routinely done particularly the outpatient setting. The sensitivity and specificity can vary. They are useful when resistant microorganisms are suspected. Bronchoscopy might be done to help improve ability to diagnose or again for resistant microorganisms. Serology such as an IgM and IgG can sometimes be helpful in determining the presence of an atypical organisms such as a mycoplasma. Urine antigens can sometimes be useful for things like strep and Legionella. PCR’s are more frequently done to detect DNA of respiratory pathogens. Blood cultures need to be drawn and all hospitalize patients diagnosed with pneumonia. This is a JACHO guideline.


20
Q

CAP: abx treatment 1st line

A

empirically treated for the most common pathogen, strep pneumonia.
1st line is a macrolide-mycin or Doxy

21
Q

CAP, treatment for suspected H. influenzae

A

azythromycin

22
Q

CAP- PCN resistance or recent abx use, use an

A

FQ

an alternative agent is beta lactic plus macrolide

23
Q

CAP- PCN resistance or recent abx use, use an

A

FQ

an alternative agent is beta lactic plus macrolide

24
Q

S pneumonia is resistant to

A

Ciprofloxacin

25
Q

CAP for ICU and non ICU treatment

A

FQ or beta lactic plus macrolide

26
Q

CAP for ICU and non ICU treatment

A

FQ or beta lactic plus macrolide - macrolide allergy substitue doxy

27
Q

ICU with pseudomonas risk

A

If the patient is at risk for pseudomonas pneumonia, you would want to change your coverage to include an antipseudomonal beta-lactam such as zosyn, cefepime, or merrem and also add one of 3 options: 1) Cipro or levo, 2) an aminoglycoside and azithro, 3) an antipneumococcal FQ like moxi or levo).

28
Q

CAP: MRSA treatment

A

If you suspect MRSA, you want to add vancomycin or Linezolid.


29
Q

Duration of therapy for CAP

A

Generally, uncomplicated cases treatment is from 7 to 10 days. More complicated cases treatment is 14 to 21 days depending on the causative pathogen.


30
Q

alternative gents for CAP

A

adequately hydrated
rests appropriately
Bronchodilators will sometimes help shortness of breath in patients who have lung diseases. Ibuprofen, aspirin, or acetaminophen can also help alleviate other symptoms.


31
Q

prevention of pneumococcal disease

A

The Prevnar 13 is recommended for use in infants and young children as well as all adults 65 years and older.
It is also recommended for patients older than 19 who have chronic conditions that can weaken their immune system.
Pneumovax is recommended for all adults 65 years and older or for high risk individuals. It is also recommended for patients 19 to 64 who smoke or have asthma.


32
Q

Prevnar 13 is recommended for which populations

A

infants
young children
adults >65
patients > 19 who are immune deficient

33
Q

Pneumovax is recommended for what population

A

all adults >65yo

patients 19 to 64 who smoke or have asthma.

34
Q

PNA in pediatric-

A

Outpatient treatment, amoxicillin or high-dose augmentin
Other agents can include IM ceftriaxone or a macrolide. Inpatient treatment of pneumonia is usually in the form of an IV cephalosporin or Unasyn plus azithromycin or clarithromycin. Patients who are in patient will usually receive cefotaxime or ceftriaxone plus azithromycin or clarithromycin


35
Q

Bronchitis

A

Bronchitis is a reversible inflammatory condition of the large elements of the tracheal bronchial tree. It is associated with a respiratory infection and does not extend into the alveoli. Acute bronchitis is a very common outpatient illness. Is usually self-limiting. A primarily occurs in the winter months and majority of the cases are viral in nature. Chronic bronchitis is a component of COPD. We will not discuss chronic bronchitis further in this lecture as it was covered in the pulmonary lecture.


36
Q

Clinical presentation of bronchitis

A

The hallmark symptom of bronchitis is a cough either productive or nonproductive. Bronchitis usually begins as an upper respiratory infection with nonspecific complaints. Other symptoms can include a sore throat, malaise, or headache. On exam you might likely find rhonchi, course breath sounds or rales. You will not see an infiltrate on a chest x-ray because this would be pneumonia. Cultures are of limited use in bronchitis and should not routinely be done.


37
Q

Acute bronchitis treatment

A

Treatment is usually focused on symptomatic and supportive relief. Medications patients can use include acetaminophen, ibuprofen, aspirin, decongestant, or cough syrup. Routine use of antibiotics is discouraged for bronchitis. Again they are usually self-limiting and primarily caused by viral pathogens. You only want to use an antibiotic if the patient has a fever which is a temperature greater than 102, COPD, symptoms lasting more than 4 to 6 days, or if you have a high suspicion that it is a bacterial infection in nature.


38
Q

Acute bronchitis treatment

A

Antibiotic treatment is dependent on the organism the general choices include ampicillin, amoxicillin, a respiratory fluoroquinolone, or doxycycline. Macrolides need to be used if you suspect mycoplasma pneumonia and Augmentin and if you suspect an atypical pathogen.


39
Q

define acute bronchitis

A

.

40
Q

define chronic bronchitis

A

.

41
Q

define bronchiolitis

A

.