Loop Diuretics Flashcards
1
Q
Examples
A
Furosemide
Bumetanide
Torsemide
2
Q
Mode of action
A
NA+/K+/2Cl- co-transporter in LoH
Inhibitor
Reduces Na+, K+, Cl- reabsorption
Most powerful diuretic = Excretion of 15-25% filtered Na+
3
Q
Indications
A
Oedema
Congestive Heart Failure
Renal failure
Resistant hypertension
4
Q
Adverse drug reactions
A
Oto + Nephrotoxicity Hypotension Hyponatraemia/kalaemia Hypercalcaemia Increase pH and Urea
5
Q
PRESCRIBING ADVICE
A
Not with w/ Aminoglycosides or NSAIDs
Works within an hour orally
Works within 5 minutes with IV furosemide
Lasts 6 hours