Loop Diuretics Flashcards

1
Q

Examples

A

Furosemide
Bumetanide
Torsemide

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2
Q

Mode of action

A

NA+/K+/2Cl- co-transporter in LoH
Inhibitor
Reduces Na+, K+, Cl- reabsorption
Most powerful diuretic = Excretion of 15-25% filtered Na+

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3
Q

Indications

A

Oedema
Congestive Heart Failure
Renal failure
Resistant hypertension

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4
Q

Adverse drug reactions

A
Oto + Nephrotoxicity
Hypotension
Hyponatraemia/kalaemia
Hypercalcaemia
Increase pH and Urea
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5
Q

PRESCRIBING ADVICE

A

Not with w/ Aminoglycosides or NSAIDs
Works within an hour orally
Works within 5 minutes with IV furosemide
Lasts 6 hours

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