K+ Sparing (Aldosterone - Dependent) Flashcards
1
Q
Examples
A
Spironolactone
2
Q
Mode of action
A
Intracellular aldosterone mineralocorticosteroid receptor in DCT
Antagonist
Prevent action of aldosterone
Reduces fluid retention and Vasoconstriction
3
Q
Indications
A
Aldosteronism Liver Ascites Resistant HTN Hypertension with hypokaleamia Oedema
4
Q
Adverse drug reactions
A
Oto and Nephrotoxicity Hypotension Hyperkalaemia Hyponatraemia Sexual dysfunction Sickness Nausea Vomiting Gynacomastia Irregular periods Confusion Dizziness Hirsuitism Skin rash
5
Q
Prescribing Advice
A
Not used w/ ACEi, ARBs, Beta-Blockers, NSAIDs
Do not use in Addison’s disease
