Local Control of Circulation

Question 1

Boosting Parasympathetic does what to a cardiac function curve?

Answer 1

Very tiny shift down and right b/c it doesn’t alter contractility.

Question 2

Which organ gets the most blood flow per weight?

Answer 2

The kidneys.

Question 3

Which organ has the highest A-V O2 Difference?

Answer 3

The heart

Question 4

Which two organs have the lowest blood flow per weight and why?

Answer 4

Muscle and skin b/c they’re not metabolically active at rest.

Question 5

2nd, 3rd, and 4th most active organs (blood flow per weight)?

Answer 5

Liver, Heart, Brain

Question 6

3 main organs that aren’t affected by sympathetics strongly?

Answer 6

1. Brain
2. Heart
3. Skeletal Muscles

Question 7

2 main organs that are affected by sympathetics strongly.

Answer 7

1. Skin

2. Kidneys

Question 8

Two types of metabolic regulation?

Answer 8

1. Active (exercise)

2. Reactive (Blockage Buildup)

Question 9

Metabolic Regulation

Answer 9

Dilation from substances such as adenosine or NO that cause a blood-flow spike

Question 10

Autoregulation (Myogenic)

Answer 10

Constriction caused by smooth muscle depolarization to regulation sudden pressure spikes. (Endothelium Independent)

Question 11

Shear-Stress effect?

Answer 11

Vasodilation driven by Overal Pressure Gradient Range increasing. Usually by NO
(Transmural pressure stays same; often a downstream effect)

Question 12

Transmural Pressure formula?

Answer 12

P=Tensionr/Radius