Elements of Vascular and Microvascular Function

Question 1

What is rarefaction

Answer 1

Reduced density of patent vessels

Question 2

Nitric Oxide 3 Steps

Answer 2

1. L-Arg + O2 mix
2. NO and L-Citrullin are made
3. cGMP is used to promote relaxation

Question 3

PGI2 Function

Answer 3

Vasodilation

Question 4

Endothelin Function

Answer 4

Vasoconstriction

Question 5

Endothelium Dependent Hyperpolarization Factor function

Answer 5

Relaxation;

Boots out K+ from the cell and makes it very negative.

Question 6

TXA-2

Answer 6

Made by platelets and promotes clotting and constriction. (Endothelium independent)

Question 7

Aggregating platelets produce ____ of smooth muscle in the presence of healthy endothelium.

Answer 7

Relaxation. (Via ADP and 5-HT signals for Histamine, Bradykini, and Thrombin)

Question 8

What’s the % volume distribution in the veins?

Answer 8

~64%

Question 9

What’s the % flow in the brain?

Answer 9

~13%

Question 10

What’s the % flow of coronary circulation?

Answer 10

~4%