Local Anesthesia

Question 1

1. Describe the mechanism of action for all local anesthetic drugs.
2. Identify the various nerve fiber types and compare how they respond to local
   anesthetic DRUGS.
3. Discuss the primary determinates related to the pharmacokinetics and
   pharmacodynamics of local anesthetics for the following:
   a. Onset time
   b. Duration
   c. Potency
4. Explain local anesthetic systemic toxicity (LAST) and demonstrate how to treat it.
5. Describe the structure of a prototypical local anesthetic molecule; name the two
   classes of local anesthetics.
6. Illustrate the structure of the voltage-gated sodium channel and diagram where
   local anesthetic drugs bind to the channel.
7. Name some common additives to local anesthetics and describe why the drugs are
   given together.
8. Recall some clinical uses for local anesthetics.

Answer 1

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