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Pharm > Antiplatelet Drugs > Flashcards

Antiplatelet Drugs Flashcards

1
Q

Why would you use an antiplatelet drug over a heparin/anticoagulant?

A

Anti-platelet drugs work better in arterial circulation.

They are widely used in primary and secondary prevention of thrombotic cerebrovascular
or cardiovascular disease

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2
Q

Aspirin:

MOA
Route of Administration
Indications
Side Effects

A

COX inhibitor (irreversible)
Oral
ACS, stroke, arterial thrombosis
Bleeding, gastric irritation

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3
Q

Clopidogrel:

MOA
Route of Administration
Indications
Side Effects

A

ADP receptor inhibitor
Oral
ACS, stroke, in stent thrombosis
Bleeding, TTP

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4
Q

Prasugrel, Ticagrelor:

MOA
Route of Administration
Indications
Side Effects

A

ADP receptor inhibitor
Oral
ACS, stroke, in stent thrombosis
Bleeding

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5
Q

NSAIDs:

MOA
Route of Administration
Indications
Side Effects

A

COX inhibitor (reversible)
Oral
Various diseases
Bleeding

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6
Q

Dipyridamole:

MOA
Route of Administration
Indications
Side Effects

A

Phosphodiesterase inhibitor
Oral
Arterial thrombosis, stroke
Bleeding

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7
Q

Cilostazol:

MOA
Route of Administration
Indications
Side Effects

A

Phosphodiesterase inhibitor
Oral
Intermittent claudication
Hypotension

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8
Q

Abciximab:

MOA
Route of Administration
Indications
Side Effects

A

GP2b3a ihibitor
IV
Acute Coronary Syndrome, Percutaneous Coronary Intervention (PCI)
Bleeding

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9
Q

Eptifibatide:

MOA
Route of Administration
Indications
Side Effects

A

GP2b3a ihibitor
IV
Acute Coronary Syndrome, Percutaneous Coronary Intervention (PCI)
Bleeding

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10
Q

Tirofiban:

MOA
Route of Administration
Indications
Side Effects

A

GP2b3a ihibitor
IV
Acute Coronary Syndrome, Percutaneous Coronary Intervention (PCI)
Bleeding

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11
Q

Why do COX inhibitors function as antiplatelet drugs?

A

COX enzymes are involved in the production of thromboxane. COX inhbitors prevent the production of thromboxane A2 by platelets

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12
Q

Why do ADP receptor inhibitors function as antiplatelet drugs?

A

ADP contributes to aggregation

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13
Q

Why do phosphodiesterase inhibitors function as antiplatelet drugs?

A

Phosphodiesterase converts cAMP to AMP, which can eventually be converted to ADP

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14
Q

Why do GP3a2b inhibitors function as antiplatelet drugs?

A

GP3a2b receptors are connected by fibrin in platelet aggregation. Blocking these receptors blocks aggregation

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15
Q

Monteleukast:

MOA
Route of Administration
Indications
Side Effects

A

Leukotriene receptor inhibitor
Oral
Allergic reaction
Hypotension, behavioral changes

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16
Q

Zafirleukast:

MOA
Route of Administration
Indications
Side Effects

A

Leukotriene receptor inhibitor
Oral
Asthma
Hypotension

17
Q

Zieton:

MOA
Route of Administration
Indications
Side Effects

A

Lipoxygenase inhibitor
Oral
Asthma
Hypotension

Pharm (22 decks)

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