Cholinergics Flashcards
1
Q
- Distinguish the main structural and functional differences between nicotinic and muscarinic receptors, including their most well recognized function, signaling mechanisms, and location in the autonomic nervous system.
A
/
2
Q
- Describe the difference between parasympathetic and nicotinic effects in the body.
A
/
3
Q
- Describe the difference in mechanism of action of directly and indirectly acting cholinergic agonists.
A
/
4
Q
- List the differences in the pharmacological activity of key quaternary nitrogen analogs of choline (e.g., nicotinic vs. muscarinic activity).
A
/
5
Q
- List the 3 key quaternary analogs of acetylcholine discussed in lecture and their pharmacological actions in the body.
A
/
6
Q
- List the prototype tertiary amine muscarinic agonist discussed in lecture and describe the major chemical feature that distinguishes it from the quaternary analogs and how this feature affects the drug’s clinical effects.
A
/
7
Q
- Describe the relative susceptibility of the quaternary analog agonists to enzymatic degradation.
A
/
8
Q
- List common clinical uses for the 4 muscarinic agonists discussed in class.
A
/
9
Q
- List 3 key representative reversible cholinesterase inhibitors discussed in lecture and describe their relative duration of action (vs. one another), and their primary clinical applications
A
/
10
Q
- Describe the mechanism of action of the irreversible cholinesterase inhibitors, and describe the mechanism by which 2-PAM can act as an antidote to irreversible cholinesterase inhibition.
A
/
11
Q
- Describe the pharmacologic effects and the treatment for organophosphate toxicity
A
/
12
Q
- Describe the dose-dependent pharmacological effects of atropine.
A
/
13
Q
- Describe the symptoms of atropine poisoning and its treatment.
A
/
14
Q
- Describe various clinical applications for atropinic agents.
A
/
15
Q
- Describe how, when and why glycopyrrolate is used during recovery from anesthesia
A
/
